Ordering Recommendation

Order to confirm a reactive treponemal screening test (eg, CIA, EIA) when using the reverse testing algorithm to screen for syphilis.


Semi-Quantitative Particle Agglutination




1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Serum separator tube (SST).

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.5 mL).  Avoid freezing if possible.

Storage/Transport Temperature


Unacceptable Conditions

Plasma, CSF, or other body fluids.


After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
Reference Interval
  Rapid Plasma Reagin (RPR) Non Reactive

Interpretive Data

Component Interpretation
Rapid Plasma Reagin (RPR) RPR (+) = Reactive
RPR (-) = Nonreactive

Compliance Category



If RPR is reactive, then a titer to endpoint will be added. If RPR is nonreactive, a TP-PA (MHA) confirmation will be added. Additional charges apply.

Hotline History


CPT Codes

86592 RPR; if reflexed, add (nonreactive) TP-PA 86780 or (reactive) 86593 RPR titer


Component Test Code* Component Chart Name LOINC
0050472 Rapid Plasma Reagin (RPR) 20507-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Rapid Plasma Reagin (RPR) with MHA-TP Confirmation
  • Rapid Plasma Reagin (RPR), Reverse Algorithm, Syphilis Reverse Algorithm
  • Rapid Plasma Reagin Reflex to Titer or TPPA
  • RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing
  • RPR Reflex to TPPA or Titer
  • RPR Reverse Algorithm
  • RPR with MHA-TP Confirmation
  • Syphilis Reverse Testing Algorithm
  • Treponema pallidum (Rapid Plasma Reagin) with Reflex to Titer & TP-PA Confirmation
Rapid Plasma Reagin (RPR) with Reflex to RPR Titer or T. pallidum Antibody by Particle Agglutination