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BRAF V600E Mutation Detection in Hairy Cell Leukemia by Real-Time PCR, Quantitative
Copy Utility
Ordering Recommendation
Confirm a diagnosis of hairy cell leukemia (HCL) and monitor tumor burden.
Mnemonic
Methodology
Polymerase Chain Reaction
Performed
DNA isolation: Sun-Sat
Testing: Varies
Reported
4-10 days
New York DOH Approval Status
Specimen Required
Lavender (EDTA) or bone marrow (EDTA). Also acceptable: DNA extracted by CLIA certified lab.
Whole Blood: Do not freeze. Transport 5 mL whole blood. (Min: 1 mL)
Bone Marrow: Transport 3 mL bone marrow. (Min: 1 mL)
Extracted DNA: Transport 40 uL DNA with at least 50 ng/uL concentration. (Min: 40 uL) Transport DNA in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.
Refrigerated.
Plasma, serum, FFPE tissue blocks/slides, or frozen tissue, DNA extracted by a non-CLIA lab. Specimens collected in anticoagulants other than EDTA or sodium heparin. Clotted or grossly hemolyzed specimens.
Ambient: 24 hours; Refrigerated: 5 days; Frozen: Unacceptable
Extracted DNA: Ambient: 1 month; Refrigerate: Indefinitely; Frozen: Indefinitely
Reference Interval
Interpretive Data
Refer to report
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
81210
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2007133 | BRAF V600E Detection Hairy Cell, Result | |
| 2007134 | BRAF V600E Detection Hairy Cell, Quant |
Aliases
- BRAF V600E
- Hairy cell leukemia BRAF testing
- Hairy cell leukemia quant PCR
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