Ordering Recommendation

Detect and quantify cytomegalovirus. Determine antiviral drug resistance to cidofovir, foscarnet sodium, and ganciclovir.




Quantitative Polymerase Chain Reaction/Sequencing




4-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Separate plasma from cells. Transfer 4 mL plasma to a sterile container. (Min: 2.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Serum. Heparinized specimens.


Ambient: 8 hours; Refrigerated: 72 hours; Frozen: 1 year

Reference Interval

Not detected

Interpretive Data

The quantitative range of this test is 2.6 - 6.6 log copies/mL (390-3,900,000 copies/mL) or 2.4 - 6.4 log IU/mL (227- 2,270,000 IU/mL). One IU/mL of CMV DNA is approximately 1.72 copies/mL.

A negative result (less than 2.6 log copies/mL [less than 390 copies/mL] OR less than 2.4 log IU/mL [less than 227 IU/mL]) does not rule out the presence of PCR inhibitors in the patient specimen or CMV DNA concentrations below the level of detection of the test. Inhibition may also lead to underestimation of viral quantitation.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Analyte Specific Reagent (ASR)


If CMV Quantitative PCR result is greater than or equal to 3.2 log (1600 copies/mL), then CMV Antiviral Drug Resistance by Sequencing will be added. Additional charges apply.

Hotline History


CPT Codes

87497; if reflexed, add 87910


Component Test Code* Component Chart Name LOINC
0051814 Cytomegalovirus Quant by PCR, Interp 40444-2
0051815 Cytomegalovirus Quant by PCR, Log Cpy/mL 53763-9
2002316 Cytomegalovirus Quant by PCR, Cpy/mL 33006-8
2006534 Cytomegalovirus Quant by PCR, IU/mL 34720-3
2006535 Cytomegalovirus Quant by PCR, Log IU/mL 96396-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • CMV genotype
  • CMV Quant PCR Drug Resistance Reflex
  • CMV quantitative
  • CMV reflex
  • herpes
  • HHV-5
  • Human herpesvirus 5
  • Viral load monitoring
Cytomegalovirus, Quantitative PCR with Reflex to Drug Resistance Testing by Sequencing (Change effective as of 11/14/22: Refer to 3005895 in the November Hotline)