Ordering Recommendation

Detect and quantify cytomegalovirus. Determine antiviral drug resistance to cidofovir, foscarnet sodium, and ganciclovir.

Mnemonic
CMV QNT GR
Methodology

Quantitative Polymerase Chain Reaction/Sequencing

Performed

Sun-Sat

Reported

4-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Separate plasma from cells. Transfer 4 mL plasma to a sterile container. (Min: 2.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Serum. Heparinized specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 72 hours; Frozen: 1 year

Reference Interval

Not detected

Interpretive Data

The quantitative range of this test is 2.6 - 6.6 log copies/mL (390-3,900,000 copies/mL) or 2.4 - 6.4 log IU/mL (227- 2,270,000 IU/mL). One IU/mL of CMV DNA is approximately 1.72 copies/mL.

A negative result (less than 2.6 log copies/mL [less than 390 copies/mL] OR less than 2.4 log IU/mL [less than 227 IU/mL]) does not rule out the presence of PCR inhibitors in the patient specimen or CMV DNA concentrations below the level of detection of the test. Inhibition may also lead to underestimation of viral quantitation.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Note

If CMV Quantitative PCR result is greater than or equal to 3.2 log (1600 copies/mL), then CMV Antiviral Drug Resistance by Sequencing will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

87497; if reflexed, add 87910

Components
Component Test Code* Component Chart Name LOINC
0051814 Cytomegalovirus Quant by PCR, Interp 40444-2
0051815 Cytomegalovirus Quant by PCR, Log Cpy/mL 54206-8
2002316 Cytomegalovirus Quant by PCR, Cpy/mL 30247-1
2006534 Cytomegalovirus Quant by PCR, IU/mL 72493-0
2006535 Cytomegalovirus Quant by PCR, Log IU/mL 72494-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CMV genotype
  • CMV Quant PCR Drug Resistance Reflex
  • CMV quantitative
  • CMV reflex
  • herpes
  • HHV-5
  • Human herpesvirus 5
  • Viral load monitoring
Cytomegalovirus, Quantitative PCR with Reflex to Drug Resistance Testing by Sequencing