Ordering Recommendation

Screen for potential SDH germline mutations in patients with certain tumor types.

Mnemonic
SDHB IP
Methodology

Immunohistochemistry

Performed

Mon-Fri

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Protect paraffin block and/or slides from excessive heat. Transport tissue block or 6 unstained (3- to 5- micron thick sections), positively charged slides in a tissue transport kit (ARUP Supply #47808) available online through eSupply using AUP Connect™ or contact ARUP Client Services at (800)522-2787. (Min. 2 slides) If sending precut slides, do not oven bake.

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens submitted with non-representative tissue type. Depleted specimens.

Remarks

IMMUNOHISTOCHEMISTRY ORDERING AND SUBMISSION DETAILS: Submit electronic request. For additional technical details, please contact ARUP Anatomic Pathology at (801)581-2507.

Stability

Ambient: Indefinite; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval
Interpretive Data

Refer to report.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note

This test code includes pathologist interpretation of results. Include surgical pathology report with specimen submitted for testing. Indicate tissue site on requisition.

Hotline History
N/A
CPT Codes

88360

Components
Component Test Code* Component Chart Name LOINC
2006949 SDHB w/Interp by IHC - Reference Number
2006950 SDHB w/Interp by IHC - Tissue Source
2006951 SDHB w/Interp by IHC - Result
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • SDHB IHC
  • SDHB immunostaining
  • Succinate Dehydrogenase B
SDHB with Interpretation by Immunohistochemistry