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SDHB with Interpretation by Immunohistochemistry
Ordering Recommendation
Screen for potential SDH germline mutations in patients with certain tumor types.
New York DOH Approval Status
Specimen Required
Tumor tissue.
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Protect paraffin block and/or slides from excessive heat. Transport tissue block or 6 unstained (3- to 5- micron thick sections), positively charged slides in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800)522-2787. (Min. 2 slides) If sending precut slides, do not oven bake.
Room temperature or refrigerated. Ship in cooled container during summer months.
Paraffin block with no tumor tissue remaining. Specimens fixed in any other fixative other than 10 percent neutral buffered formalin. Decalcified specimens.
IMMUNOHISTOCHEMISTRY ORDERING AND SUBMISSION DETAILS: Submit electronic request. For additional technical details, please contact ARUP Anatomic Pathology at (801)581-2507.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinite; Refrigerated: Indefinitely; Frozen: Unacceptable
Methodology
Immunohistochemistry
Performed
Mon-Fri
Reported
1-5 days
Reference Interval
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
This test code includes pathologist interpretation of results. Include surgical pathology report with specimen submitted for testing. Indicate tissue site on requisition.
Hotline History
CPT Codes
88360
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2006949 | SDHB w/Interp by IHC - Reference Number | 94736-6 |
| 2006950 | SDHB w/Interp by IHC - Tissue Source | 31208-2 |
| 2006951 | SDHB w/Interp by IHC - Result | 55229-9 |
Aliases
- SDHB IHC
- SDHB immunostaining
- Succinate Dehydrogenase B
