Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
Recommended test for the surveillance of residual/recurrent thyroid cancer. Accurately measures thyroglobulin levels in serum or plasma.
MnemonicUnique test identifier.
THYROGRFX
MethodologyProcess(es) used to perform the test.
Quantitative Chemiluminescent Immunoassay/High Performance Chromatography-Tandem Mass
PerformedDays of the week the test is performed.
Sun-Sat
ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
1-7 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect
Serum Separator Tube (SST). Also acceptable: Green (Sodium or Lithium Heparin).
Specimen Preparation
Transfer 3 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)
Storage/Transport Temperature
Frozen.
Unacceptable Conditions
EDTA or K2EDTA Plasma. Any fluid other than noted above. (See Thyroglobulin, Fine Needle Aspiration (FNA) (ARUP test code 0020753) for ordering alternate fluids).
Remarks
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: 1 week; Frozen: 6 months
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Specimens negative for thyroglobulin antibodies (TgAb) are tested for thyroglobulin (Tg) by chemiluminescent immunoassay (CIA) using the Beckman Coulter Access DxI method. Specimens with TgAb results above the upper reference limit are tested for Tg by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results obtained with different test methods or kits cannot be used interchangeably. Tg results, regardless of concentration, should not be interpreted as absolute evidence for the presence or absence of papillary or follicular thyroid cancer. Tg testing is not recommended for use as a screening procedure to detect the presence of thyroid cancer in the general population.
Lower limit of detection for Thyroglobulin by LC-MS/MS is 0.5 ng/mL.
Compliance Category
FDA
NoteAdditional information related to the test.
The reflex testing method (CIA or LC-MS/MS) is determined by the TgAb result. Additional charges apply.
Hotline History
N/A
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.
Anti Thyroglobulin Antibody
HTG
Human Thyroglobulin
TATC
Tg
Thyroglobulin
Thyroglobulin Antibody
Thyroglobulin Assay for Thyroid Cancer
Thyroglobulin HTC
Thyroglobulin, Serum or Plasma with Reflex to LC-MS/MS or CIA