Ordering Recommendation

Use to detect and document fetal drug exposure during approximately the last trimester of a full-term pregnancy. For panel testing that includes THC metabolite, refer to Drug Detection Panel and THC Metabolite, Umbilical Cord Tissue, Qualitative (3006371).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Umbilical Cord (At least 8 inches, approximately the width of a sheet of paper.)

Specimen Preparation

Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or water. Pat the cord dry and transport at least 8 inches of umbilical cord in a routine urine collection cup or Security Kit for Meconium/Umbilical Drug Detection (ARUP supply #51548) available online through eSupply using ARUP Connect™ or by contacting ARUP Client Services at (800) 522-2787.

Storage/Transport Temperature


Unacceptable Conditions

Cords soaking in blood or other fluid. Formalin fixed. Tissue that is obviously decomposed.


Ambient: 1 week; Refrigerated: 3 weeks; Frozen: 1 year


Qualitative Liquid Chromatography-Tandem Mass Spectrometry




1-3 days

Reference Interval

Effective February 20, 2018

Drugs covered and range of cutoff concentrations.
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Buprenorphine 1 Amphetamine 5
Norbuprenorphine 0.5 Benzoylecgonine 1
m-OH-Benzoylecgonine 1
Codeine 0.5 Cocaethylene 1
Dihydrocodeine 1 Cocaine 1
Fentanyl 0.5 MDMA (Ecstasy) 5
Hydrocodone 0.5 Methamphetamine 5
Norhydrocodone 1 Phentermine 8
Hydromorphone 0.5 Alprazolam 0.5
Meperidine 2 Alpha-OH-Alprazolam 0.5
Methadone 2 Butalbital 25
Methadone metabolite 1 Clonazepam 1
6-Acetylmorphine 1 7-Aminoclonazepam 1
Morphine 0.5 Diazepam 1
Naloxone 1 Lorazepam 5
Oxycodone 0.5 Midazolam 1
Noroxycodone 1 Alpha-OH-Midazolam 2
Oxymorphone 0.5 Nordiazepam 1
Noroxymorphone 0.5 Oxazepam 2
Propoxyphene 1 Phenobarbital 75
Tapentadol 2 Temazepam 1
Tramadol 2 Zolpidem 0.5
N-desmethyltramadol 2 Phencyclidine (PCP) 1
O-desmethyltramadol 2 Gabapentin 10

Interpretive Data

Methodology: Qualitative Liquid Chromatography/Tandem Mass Spectrometry

Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during approximately the last trimester of a full-term pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Absolute Minimum:  6 inches. For marijuana metabolite, order Marijuana Metabolite, Umbilical Cord Tissue, Qualitative (ARUP test code 3000256). For alcohol metabolite, order Ethyl Glucuronide, Umbilical Cord Tissue, Qualitative (ARUP test code 3000443).
For kratom metabolite, order Kratom, Umbilical Cord, Qualitative (ARUP test code 3005874)
When ordering multipleumbilical cord tests, unless ARUP is otherwise notified, testing will be performed in the following order of priority:

Drug Detection Panel (1.0g)
Marijuana Metabolite (1.0g)
Ethyl Glucuronide (1.0g)
Kratom(1.0 g)

Hotline History


CPT Codes

80326; 80347; 80364; 80355 (Alt code: G0481)


Component Test Code* Component Chart Name LOINC
2006622 Drug Detection Panel, Umbilical Cord 62364-5
2006626 Buprenorphine, Cord, Qual 82373-2
2006628 Codeine, Cord, Qual 40626-4
2006629 Dihydrocodeine, Cord, Qual 97242-2
2006630 Fentanyl, Cord, Qual 61042-8
2006631 Hydrocodone, Cord, Qual 32080-4
2006632 Hydromorphone, Cord, Qual 32081-2
2006633 Meperidine, Cord, Qual 32088-7
2006634 Methadone, Cord, Qual 32093-7
2006635 Methadone Metabolite, Cord, Qual 41859-0
2006636 6-Acetylmorphine, Cord, Qual 32099-4
2006637 Morphine, Cord, Qual 32100-0
2006638 Naloxone, Cord, Qual 100357-3
2006640 Oxycodone, Cord, Qual 32101-8
2006641 Oxymorphone, Cord, Qual 91053-9
2006642 Propoxyphene, Cord, Qual 43811-9
2006644 Tapentadol, Cord, Qual 59355-8
2006645 Tramadol, Cord, Qual 97306-5
2006646 N-desmethyltramadol, Cord, Qual 97306-5
2006647 O-desmethyltramadol, Cord, Qual 97292-7
2006648 Amphetamine, Cord, Qual 29530-3
2006649 Benzoylecgonine, Cord, Qual 40609-0
2006650 m-OH-Benzoylecgonine, Cord, Qual 43230-2
2006652 Cocaethylene, Cord, Qual 48946-8
2006653 Cocaine, Cord, Qual 40625-6
2006654 MDMA- Ecstasy, Cord, Qual 40481-4
2006657 Methamphetamine, Cord, Qual 40381-6
2006658 Phentermine, Cord, Qual 100358-1
2006659 Alprazolam, Cord, Qual 61038-6
2006660 Alpha-OH-Alprazolam, Cord, Qual 61037-8
2006662 Butalbital, Cord, Qual 32057-2
2006663 Clonazepam, Cord, Qual 61039-4
2006664 7-Aminoclonazepam, Cord, Qual 61031-1
2006665 Diazepam, Cord, Qual 61074-1
2006671 Lorazepam, Cord, Qual 61044-4
2006672 Midazolam, Cord, Qual 59712-0
2006673 Alpha-OH-Midazolam, Cord, Qual 97278-6
2006675 Nordiazepam, Cord, Qual 61051-9
2006676 Oxazepam, Cord, Qual 61055-0
2006677 Phenobarbital, Cord, Qual 32108-3
2006679 Temazepam, Cord, Qual 61061-8
2006682 Zolpidem, Cord, Qual 97310-7
2006683 Phencyclidine- PCP, Cord, Qual 32107-5
2009199 EER Drug Detection Pan, Umbilical Cord 11526-1
2013103 Norbuprenorphine, Cord, Qual 82375-7
2013104 Norhydrocodone, Cord, Qual 97286-9
2013105 Noroxycodone, Cord, Qual 97290-1
2013106 Noroxymorphone, Cord, Qual 97296-8
3001452 Gabapentin, Cord, Qual 93121-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Drug Screen, Targeted, Serum or Plasma
  • Drugs of Abuse Panel, Meconium - Screen with Reflex to Confirmation/Quantitation
Drug Detection Panel, Umbilical Cord Tissue, Qualitative