Ordering Recommendation

Detect and document maternal drug use. Useful during approximately the last trimester of a full-term pregnancy. To test for marijuana metabolite, see Marijuana Metabolite, Umbilical Cord Tissue, Qualitative (3000256). To test for ethyl glucuronide, see Ethyl Glucuronide, Umbilical Cord Tissue, Qualitative (3000443).

Mnemonic
TOF SCR CD
Methodology

Qualitative Liquid Chromatography/Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Umbilical Cord (At least 8 inches, approximately the width of a sheet of paper.)

Specimen Preparation

Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or water. Pat the cord dry and transport at least 8 inches of umbilical cord in a routine urine collection cup or Security Kit for Meconium/Umbilical Drug Detection (ARUP supply #51548) available online through eSupply using ARUP Connect™ or by contacting ARUP Client Services at (800) 522-2787.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Cords soaking in blood or other fluid. Formalin fixed. Tissue that is obviously decomposed.

Remarks
Stability

Ambient: 1 week; Refrigerated: 3 weeks; Frozen: 1 year

Reference Interval

Effective February 20, 2018

Drugs covered and range of cutoff concentrations.
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Buprenorphine 1 Amphetamine 5
Norbuprenorphine 0.5 Benzoylecgonine 0.5
m-OH-Benzoylecgonine 1
Codeine 0.5 Cocaethylene 1
Dihydrocodeine 1 Cocaine 0.5
Fentanyl 0.5 MDMA (Ecstasy) 5
Hydrocodone 0.5 Methamphetamine 5
Norhydrocodone 1 Phentermine 8
Hydromorphone 0.5 Alprazolam 0.5
Meperidine 2 Alpha-OH-Alprazolam 0.5
Methadone 2 Butalbital 25
Methadone metabolite 1 Clonazepam 1
6-Acetylmorphine 1 7-Aminoclonazepam 1
Morphine 0.5 Diazepam 1
Naloxone 1 Lorazepam 5
Oxycodone 0.5 Midazolam 1
Noroxycodone 1 Alpha-OH-Midazolam 2
Oxymorphone 0.5 Nordiazepam 1
Noroxymorphone 0.5 Oxazepam 2
Propoxyphene 1 Phenobarbital 75
Tapentadol 2 Temazepam 1
Tramadol 2 Zolpidem 0.5
N-desmethyltramadol 2 Phencyclidine (PCP) 1
O-desmethyltramadol 2 Gabapentin 10

Interpretive Data

Methodology: Qualitative Liquid Chromatography/Tandem Mass Spectrometry

Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during approximately the last trimester of a full-term pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note

Absolute Minimum:  6 inches. For marijuana metabolite, order Marijuana Metabolite, Umbilical Cord Tissue, Qualitative (ARUP test code 3000256). For alcohol metabolite, order Ethyl Glucuronide, Umbilical Cord Tissue, Qualitative (ARUP test code 3000443).

Hotline History
N/A
CPT Codes

80307

Components
Component Test Code* Component Chart Name LOINC
2006622 Drug Detection Panel, Umbilical Cord 62364-5
2006626 Buprenorphine, Cord, Qual
2006628 Codeine, Cord, Qual 40626-4
2006629 Dihydrocodeine, Cord, Qual
2006630 Fentanyl, Cord, Qual 61042-8
2006631 Hydrocodone, Cord, Qual 32080-4
2006632 Hydromorphone, Cord, Qual 32081-2
2006633 Meperidine, Cord, Qual 32088-7
2006634 Methadone, Cord, Qual 32093-7
2006635 Methadone Metabolite, Cord, Qual 41859-0
2006636 6-Acetylmorphine, Cord, Qual 32099-4
2006637 Morphine, Cord, Qual 32100-0
2006638 Naloxone, Cord, Qual
2006640 Oxycodone, Cord, Qual 32101-8
2006641 Oxymorphone, Cord, Qual
2006642 Propoxyphene, Cord, Qual 43811-9
2006644 Tapentadol, Cord, Qual
2006645 Tramadol, Cord, Qual
2006646 N-desmethyltramadol, Cord, Qual
2006647 O-desmethyltramadol, Cord, Qual
2006648 Amphetamine, Cord, Qual 29530-3
2006649 Benzoylecgonine, Cord, Qual 40609-0
2006650 m-OH-Benzoylecgonine, Cord, Qual
2006652 Cocaethylene, Cord, Qual
2006653 Cocaine, Cord, Qual 40625-6
2006654 MDMA- Ecstasy, Cord, Qual 40481-4
2006657 Methamphetamine, Cord, Qual 40381-6
2006658 Phentermine, Cord, Qual
2006659 Alprazolam, Cord, Qual 61038-6
2006660 Alpha-OH-Alprazolam, Cord, Qual 61037-8
2006662 Butalbital, Cord, Qual 32057-2
2006663 Clonazepam, Cord, Qual 61039-4
2006664 7-Aminoclonazepam, Cord, Qual 61031-1
2006665 Diazepam, Cord, Qual 61074-1
2006671 Lorazepam, Cord, Qual 61044-4
2006672 Midazolam, Cord, Qual
2006673 Alpha-OH-Midazolam, Cord, Qual
2006675 Nordiazepam, Cord, Qual 61051-9
2006676 Oxazepam, Cord, Qual 61055-0
2006677 Phenobarbital, Cord, Qual 32108-3
2006679 Temazepam, Cord, Qual 61061-8
2006682 Zolpidem, Cord, Qual
2006683 Phencyclidine- PCP, Cord, Qual 32107-5
2009199 EER Drug Detection Pan, Umbilical Cord 11526-1
2013103 Norbuprenorphine, Cord, Qual
2013104 Norhydrocodone, Cord, Qual
2013105 Noroxycodone, Cord, Qual
2013106 Noroxymorphone, Cord, Qual
3001452 Gabapentin, Cord, Qual 93121-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Drug Screen, Targeted, Serum or Plasma
  • Drugs of Abuse Panel, Meconium - Screen with Reflex to Confirmation/Quantitation
Drug Detection Panel, Umbilical Cord Tissue, Qualitative