Panel to evaluate for inherited and acquired thrombophilias.
Chromogenic Assay/Electromagnetic Mechanical Clot Detection/Quantitative Enzymatic/Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Polymerase Chain Reaction/Fluorescence Monitoring/Microlatex Particle Mediated Immunoassay
Varies
2-7 days
Fasting preferred. Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Four Light Blue (Sodium Citrate) AND two Lavender (EDTA) AND two Serum Separator Tubes (SST). Also acceptable in place of one of the Serum Separator Tubes (SST): Green (Sodium or Lithium Heparin) or EDTA (K2 or K3).
One Serum Separator Tube (SST), Green (Sodium or Lithium Heparin) or EDTA (K2 or K3) must be centrifuged and serum or plasma separated within 1 hour of collection. Transfer 1 mL centrifuged serum or plasma to ARUP Standard Transport Tube and label centrifuged tube for homocysteine testing. (Min: 0.5 mL) AND Transfer 2 mL serum into 2 ARUP Standard Transport Tubes, label as serum. (Min: 0.5 mL/tube) AND Transfer 7.5 mL platelet poor plasma prepared from the sodium citrate tubes to 5 ARUP Standard Transport Tubes, label as sodium citrate. (Min: 1 mL/tube) AND Transfer 3 mL lavender whole blood to 2 ARUP Standard Transport Tubes. (Min: 1 mL/tube)
Light Blue (Sodium Citrate): CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Lavender Whole Blood and Serum, Green (Sodium or Lithium Heparin) or EDTA (K2 or K3): Refrigerated.
Specimens collected in any tube type not listed above.
Light Blue (Sodium Citrate): Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 2 weeks
Lavender Whole Blood: Ambient: 2 hours; Refrigerated: 1 week; Frozen: Unacceptable
Serum: Ambient: 2 hours; Refrigerated: 1 week; Frozen: 2 weeks
Green (Sodium or Lithium Heparin) or EDTA (K2 or K3): Ambient: 4 days; Refrigerated: 1 month; Frozen: 10 months
Test Number |
Components |
Reference Interval |
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Prothrombin Time | 12.0-15.5 seconds | |||||||||||||||||||||||||||||
Dilute Russell Viper Venom Time (dRVVT) | 33-44 seconds | |||||||||||||||||||||||||||||
Dilute Russell Viper Venom (dRVVT) 1:1 Mix (performed if dRVVT > 44 seconds) | 33-44 seconds | |||||||||||||||||||||||||||||
Dilute Russell Viper Venom Time (dRVVT) Confirmation Test (performed if dRVVT 1:1 Mix > 44 seconds) | Negative | |||||||||||||||||||||||||||||
Partial Thromboplastin Time | 32-48 seconds | |||||||||||||||||||||||||||||
Thrombin Time | 14.7-19.5 seconds | |||||||||||||||||||||||||||||
Reptilase Time | Less than 22.0 seconds | |||||||||||||||||||||||||||||
PTT Heparin Neutralized | 32-48 seconds | |||||||||||||||||||||||||||||
Partial Thromboplastin Time 1:1 Mix (performed if PTT > 48 seconds) | 32-48 seconds | |||||||||||||||||||||||||||||
Platelet Neutralization Procedure (performed if PTT 1:1 Mix > 48 seconds) | Negative | |||||||||||||||||||||||||||||
Hexagonal Phospholipid Neutralization | Negative | |||||||||||||||||||||||||||||
0050901 | Cardiolipin Antibody, IgG | Effective August 18, 2014
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0050902 | Cardiolipin Antibody, IgM | Effective August 18, 2014
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Beta-2 Glycoprotein 1 Antibody, IgG | Effective August 18, 2014 0-20 SGU |
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Beta-2 Glycoprotein 1 Antibody, IgM | Effective August 18, 2014 0-20 SMU |
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0098894 | Protein S Free, Antigen |
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0099869 | Homocysteine, Total | Effective January 4, 2021: 0-15 µmol/L, for both male and female |
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0030010 | Antithrombin, Enzymatic (Activity) |
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0030113 | Protein C, Functional | Effective November 17, 2014
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APC Resistance | Effective February 21, 2011 2.00 or greater
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Factor V Leiden by PCR & Fluorescence Monitoring | Negative: The sample is negative for factor V Leiden, R506Q mutation. | |||||||||||||||||||||||||||||
0056060 | Prothrombin (F2) c.*97G>A (G20210A) Pathogenic Variant |
Refer to individual components.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Laboratory Developed Test (LDT)
Hotline History
86147 x2; 86146 x2; 85306; 83090; 85300; 85303; 85307; 85610; 81240; 85730; 85613. If PTT is abnormal, add 85670. If Thrombin time is abnormal, add 85635, 85730 and 85525. If PTT Heparin Neutralization is abnormal, add 85732. If PTT 1:1 Mix is abnormal, add 85597. If dRVVT is abnormal, add 85613. If dRVVT 1:1 mix is abnormal, add 85613. If PNP and dRVVT confirmation are normal, add 85598. If APC resistance is low, add 81241.
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0030010 | Antithrombin, Enzymatic (Activity) | 27811-9 |
0030054 | Thrombosis Interpretation - Risk | |
0030079 | Lupus Anticoagulant Interpretation | 75882-1 |
0030082 | Hexagonal Phospholipid Neutral Reflex | 33930-9 |
0030084 | PTT-D Heparin Neutralized | 52123-7 |
0030113 | Protein C Functional | 27819-2 |
0030184 | Platelet Neutralization (PTT-D, Confirm) | 15191-0 |
0030189 | dRVVT Confirmation | 50410-0 |
0030193 | APC Resistance | 13590-5 |
0030194 | Factor V Leiden by PCR | 21668-9 |
0030232 | PTT-LA Screen (PTT-D) | 34571-0 |
0030246 | Prothrombin Time | 5902-2 |
0030270 | Thrombin Time | 3243-3 |
0030296 | Reptilase Time | 6683-7 |
0030323 | PTT-D 1:1 Mix | 5946-9 |
0030352 | dRVVT Screen | 6303-2 |
0030353 | dRVVT 1:1 Mix | 75513-2 |
0050322 | B2Glycoprotein 1, IgG Antibody | 44448-9 |
0050323 | B2Glycoprotein 1, IgM Antibody | 44449-7 |
0050901 | Cardiolipin Antibody IgG | 3181-5 |
0050902 | Cardiolipin Antibody IgM | 3182-3 |
0056060 | Prothrombin (F2) G20210A Variant | 24475-6 |
0098894 | Protein S Ag Free | 27821-8 |
0099869 | Homocysteine, Total | 13965-9 |
2001308 | FACV REF Specimen | 31208-2 |
2001334 | PT PCR Specimen | 31208-2 |