Products of Conception, Ploidy by Flow Cytometry

2006178
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Example Reports
Diploid
Enhanced Report
Triploid

Ordering Recommendation

Distinguish between partial hydatiform mole (PHM) and complete hydatiform mole (CHM).

Mnemonic

DNA HYDAT

Methodology

Quantitative Flow Cytometry

Performed

Sun, Tue

Reported

3-9 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Products of conception in paraffin tissue block.

Specimen Preparation

Paraffin embed products of conception in a tissue block 

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

No tissue remaining on the block. Specimens fixed in Bouin's Solution (picric acid), fixatives containing mercuric chloride (e.g. B5, Zenker's solution) or ethanol-based fixatives containing ethylene glycol, acetic acid, or zinc chloride.  Decalcified specimens.

Remarks

Include H&E stained slide and surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

Interpretive Data

Flow Cytometry can be used to help identify partial hydatidiform moles. Partial moles are usually triploid while complete moles are diploid or tetraploid. [Clinical Medicine: Pathology, 2008, 1:61-67]. However, most products of conception are diploid by flow cytometry, so a diploid histogram does not suggest a complete hydatidiform mole unless supported clinically and microscopically. Of 35 cases of histologically apparent partial moles, no complications occurred in those that were triploid. However, 20 percent of those that were diploid had complications (persistence, metastasis). [Am J Ob Gyn, 1987, 157: 969-73]

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

A thin section of each tissue submitted is stained with H&E. The DNA content is classified as diploid, triploid, tetraploid or aneuploid. The DNA index is the ratio of the DNA content of abnormal cells compared to normal cells.

Hotline History

N/A

CPT Codes

88182

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Components

Component Test Code* Component Chart Name LOINC
0095737 Source: 31208-2
2006308 POC - DNA Analysis 30911-2
2008898 POC - DNA Index 30912-0
2010872 EER DNA, POC 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • DNA Ploidy for Hydatidiform Moles
  • Partial and Complete Hydatidiform Moles
  • Partial or Complete Hydatidiform Moles
  • Products of Conception
Products of Conception, Ploidy by Flow Cytometry