Products of Conception, Ploidy by Flow Cytometry

2006178
copy
 

Copy Utility


emailprint
Example Reports
Diploid
Enhanced Report
Triploid
Ordering Recommendation

Distinguish between partial hydatiform mole (PHM) and complete hydatiform mole (CHM).

Mnemonic
DNA HYDAT
Methodology

Quantitative Flow Cytometry

Performed

Sun, Tue

Reported

3-9 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Products of conception in paraffin tissue block.

Specimen Preparation

Paraffin embed products of conception in a tissue block 

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

No tissue remaining on the block. Specimens fixed in Bouin's Solution (picric acid), fixatives containing mercuric chloride (e.g. B5, Zenker's solution) or ethanol-based fixatives containing ethylene glycol, acetic acid, or zinc chloride.  Decalcified specimens.

Remarks

Include H&E stained slide and surgical pathology report.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval
Interpretive Data

Flow Cytometry can be used to help identify partial hydatidiform moles. Partial moles are usually triploid while complete moles are diploid or tetraploid. [Clinical Medicine: Pathology, 2008, 1:61-67]. However, most products of conception are diploid by flow cytometry, so a diploid histogram does not suggest a complete hydatidiform mole unless supported clinically and microscopically. Of 35 cases of histologically apparent partial moles, no complications occurred in those that were triploid. However, 20 percent of those that were diploid had complications (persistence, metastasis). [Am J Ob Gyn, 1987, 157: 969-73]

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note

A thin section of each tissue submitted is stained with H&E. The DNA content is classified as diploid, triploid, tetraploid or aneuploid. The DNA index is the ratio of the DNA content of abnormal cells compared to normal cells.

Hotline History
N/A
CPT Codes

88182

Are you an ARUP Client? Click here for your pricing.
Components
Component Test Code* Component Chart Name LOINC
0095737 Source: 31208-2
2006308 POC - DNA Analysis 30911-2
2008898 POC - DNA Index 30912-0
2010872 EER DNA, POC 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • DNA Ploidy for Hydatidiform Moles
  • Partial and Complete Hydatidiform Moles
  • Partial or Complete Hydatidiform Moles
  • Products of Conception
Products of Conception, Ploidy by Flow Cytometry