Time Sensitive


Cytogenetic Test Request Form Recommended (ARUP form #43098)
Ordering Recommendation

Useful to ensure the highest chance of obtaining meaningful results from fetal specimens. When tissue culture is unsuccessful or if the results of the chromosome analysis are normal, then testing reflexes to genomic microarray.


Giemsa Band/Genomic Microarray (Oligo-SNP Array)




2-3 weeks

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation

Thaw media prior to tissue inoculation. Products of conception in a sterile, screw-top container (Wide mouth containers: ARUP supply #42710) filled with tissue culture transport medium (ARUP Supply #32788). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, sterile saline, or ringers.
If autopsy is performed: Facia lata, diaphragm, tendon, skin, tissue from internal organs (if fresh), chest wall cartilage (particularly if macerated) or placenta from fetal side.
If no autopsy is performed:
Placenta from fetal side is preferred (e.g. villi). 
Also acceptable: Umbilical cord or Achilles tendon.

Specimen Preparation

DO NOT FREEZE. Do not place in formalin. Transport products of conception (min: 5mg) in sterile, screw-top container filled with tissue transport medium. If specimen size is too large for a normal collection tube, a larger sterile container can be used such as a sterile urine cup and can be flooded with several tubes of cytogenetic tissue media.

Storage/Transport Temperature

Room temperature (fresh tissue or culture flask). Also acceptable: Refrigerated.

Unacceptable Conditions

Frozen specimens. Intact fetus. Specimens preserved in formalin. Specimens consisting of maternal tissue (decidua) only. Autolyzed or contaminated specimens


If specimen collection time is greater than 72 hours, testing may be compromised. The laboratory will make every attempt to culture the specimen. Send specimen to lab for testing.


Ambient: 48 hours; Refrigerated:48 hours; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report

Compliance Statement C: For human genetic inheritable conditions and mutations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.


The chromosome analysis studies involve culturing of living cells; therefore, turnaround times given represent average times which are subject to multiple variables. After specimen receipt, results are generally available in an average of 14 days with 7-14 additional days required for microarray. 

A processing fee will be charged if the client cancels this procedure after the test has been set up, or if the specimen integrity is inadequate to allow culture growth.

When the result of Chromosome Analysis is either "no growth" or "normal," then Genomic Microarray testing will be added. Additional charges apply.

This test must be ordered using Cytogenetic test request form #43098 or through your ARUP interface. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65).

Hotline History
CPT Codes

88262; 88233; 88291; If reflexed, add 81229

Component Test Code* Component Chart Name LOINC
0097645 Chromosome Analysis, Prod Concp 48819-7
2006187 EER Chrom Analysis POC w/Rflx to Array
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • aCGH
  • Array Comparative Genomic Hybridization
  • Autopsy (ONLY if Chromosomes are indicated)
  • CGH
  • Chromosomal Microarray
  • Chromosome Analysis with reflex to microarray, Stillbirth or Miscarriage
  • Chromosome Analysis, Stillbirth or Miscarriage
  • CMA
  • comparative genomic hybridization
  • Congenital Array
  • Constitutional Array
  • intrauterine fetal demise
  • IUFD
  • Karyotype, Stillbirth or Miscarriage
  • karyotypes
  • Miscarriage
  • missed abortion
  • Molecular Karyotype
  • monosomy
  • Oligo Array
  • Oligoarray
  • Oligonucleotide Array
  • Pregnancy loss
  • SAB
  • Single-nucleotide-polymorphism (SNP) array
  • Spontaneous abortion
  • Trisomy
  • Whole Genome Array
Chromosome Analysis, Products of Conception, with Reflex to Genomic Microarray