Time Sensitive


Cytogenetic Test Request Form Recommended (ARUP form #43098)

Ordering Recommendation

Useful to ensure the highest chance of obtaining meaningful results from fetal specimens. When tissue culture is unsuccessful or if the results of the chromosome analysis are normal, then testing reflexes to genomic microarray.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation

Thaw media prior to tissue inoculation. Products of conception in a sterile, screw-top container (Wide mouth containers: ARUP supply #42710) filled with tissue culture transport medium (ARUP Supply #32788). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, sterile saline, or ringers.
If autopsy is performed: Facia lata, diaphragm, tendon, skin, tissue from internal organs (if fresh), chest wall cartilage (particularly if macerated) or placenta from fetal side.
If no autopsy is performed:
Placenta from fetal side is preferred (e.g. villi). 
Also acceptable: Umbilical cord or Achilles tendon.

Specimen Preparation

DO NOT FREEZE. Do not place in formalin. Transport products of conception (min: 5mg) in sterile, screw-top container filled with tissue transport medium. If specimen size is too large for a normal collection tube, a larger sterile container can be used such as a sterile urine cup and can be flooded with several tubes of cytogenetic tissue media.

Storage/Transport Temperature

Room temperature (fresh tissue or culture flask). Also acceptable: Refrigerated.
New York State Clients: Refrigerated

Unacceptable Conditions

Frozen specimens. Intact fetus. Specimens preserved in formalin. Specimens consisting of maternal tissue (decidua) only. Autolyzed or contaminated specimens


New York State Clients: Testing is only approved for Chromosome Analysis. Reflex testing will not be performed.


Ambient: 48 hours; Refrigerated:48 hours; Frozen: Unacceptable


Giemsa Band/Genomic Microarray (Oligo-SNP Array)




14-21 days
If reflexed, add 10-15 days.

Reference Interval

By report

Interpretive Data

Refer to report

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)


The chromosome analysis studies involve culturing of living cells; therefore, turnaround times given represent average times, which are subject to multiple variables.

A processing fee will be charged if the client cancels this procedure after the test has been set up or if the specimen integrity is inadequate to allow culture growth.

When the result of Chromosome Analysis is either "no growth" or "normal," then Genomic Microarray testing will be added. Additional charges apply.

This test must be ordered using Cytogenetic test request form #43098 or through your ARUP interface. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65).

Hotline History


CPT Codes

88262; 88233; If reflexed, add 81229


Component Test Code* Component Chart Name LOINC
0097645 Chromosome Analysis, Prod Concp 48819-7
2006187 EER Chrom Analysis POC w/Rflx to Array 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • aCGH
  • Array Comparative Genomic Hybridization
  • Autopsy (ONLY if Chromosomes are indicated)
  • CGH
  • Chromosomal Microarray
  • Chromosome Analysis with reflex to microarray, Stillbirth or Miscarriage
  • Chromosome Analysis, Stillbirth or Miscarriage
  • CMA
  • comparative genomic hybridization
  • Congenital Array
  • Constitutional Array
  • intrauterine fetal demise
  • IUFD
  • Karyotype, Stillbirth or Miscarriage
  • karyotypes
  • Miscarriage
  • missed abortion
  • Molecular Karyotype
  • monosomy
  • Oligo Array
  • Oligoarray
  • Oligonucleotide Array
  • Pregnancy loss
  • SAB
  • Single-nucleotide-polymorphism (SNP) array
  • Spontaneous abortion
  • Trisomy
  • Whole Genome Array
Chromosome Analysis, Products of Conception, with Reflex to Genomic Microarray