Ordering Recommendation

Acceptable reflexive panel for diagnosing myasthenia gravis. Includes acetylocholine receptor (AChR) binding and blocking antibodies, titin anibodies, and striated muscle antibodies, with possible reflex to AChR modulating antibodies or striated muscle antibody titer.




Quantitative Radioimmunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Semi-Quantitative Flow Cytometry




1-8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Plain red top or Serum Separator Tube (SST).

Specimen Preparation

Transport 1.5 mL serum. (Min. 0.7 mL) Separate serum from cells ASAP or within one hour of collection. Transfer to an ARUP Standard Transport Tube.

Storage/Transport Temperature

Refrigerated. Frozen is also acceptable. 

Unacceptable Conditions

Plasma. Hemolyzed, lipemic, moderately icteric serum or contaminated specimens.


Repeated freeze-thaw cycles should be avoided.


Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Test Number
Reference Interval
0080009 Acetylcholine Receptor Binding Antibody
Negative 0.0-0.4 nmol/L
Positive 0.5 nmol/L or greater

0099580 Acetylcholine Receptor Blocking Antibody Effective November 18, 2013
Negative: 0-26% blocking
Indeterminate: 27-41% blocking
Positive: 42% or greater blocking

0099521 Acetylcholine Receptor Modulating Antibody Effective August 20, 2012
Negative 0-45% modulating
Positive 46% or greater modulating

2005636 Titin Antibody Effective January 17, 2012
Titin Antibody
Negative 0.00-0.45 IV
Indeterminate 0.46-0.71 IV
Positive 0.72 IV or greater

0050746 Striated Muscle Antibodies, IgG with Reflex to Titer Less than 1:40

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Analyte Specific Reagent (ASR)


If Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L or Acetylcholine Receptor Blocking Antibody result is greater than 26 percent, then Acetylcholine Receptor Modulating Antibody will be added. If Striated Muscle Ab is detected, then a titer will be added. Additional charges apply.

Hotline History


CPT Codes

83519; 83516 x2; 86255;  if reflexed, add 83516 and/or 86256


Component Test Code* Component Chart Name LOINC
0050747 Striated Muscle Antibodies, IgG Screen 49692-7
0080009 Acetylcholine Binding Antibody 11034-6
0099580 Acetylcholine Blocking Antibody 42937-3
2005637 Titin Antibody
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • AChR Binding Antibody
  • AChR Antibody
  • Anti-Skeletal Muscle IgG Antibodies
  • Anti-Striated Antibody
  • anti-tintin Ab
  • Muscle (Skeletal) Antibodies
  • Muscle nicotinic Acetylcholine Receptor
  • Myasthenia Gravis Antibodies
  • Myoid Antibody
  • Skeletal Muscle Antibodies
  • Striational Antibodies
Acetylcholine Receptor Antibodies and Striated Muscle Antibodies Reflexive Panels, and Titin Antibody