Acetylcholine Receptor Antibodies and Striated Muscle Antibodies Reflexive Panels, and Titin Antibody
Acceptable reflexive panel for diagnosing myasthenia gravis. Includes acetylocholine receptor (AChR) binding and blocking antibodies, titin anibodies, and striated muscle antibodies, with possible reflex to AChR modulating antibodies or striated muscle antibody titer.
Quantitative Radioimmunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Semi-Quantitative Flow Cytometry
New York DOH Approval Status
Plain red top or Serum Separator Tube (SST).
Transport 1.5 mL serum. (Min. 0.7 mL) Separate serum from cells ASAP or within one hour of collection. Transfer to an ARUP Standard Transport Tube.
Refrigerated. Frozen is also acceptable.
Plasma. Hemolyzed, lipemic, moderately icteric serum or contaminated specimens.
Repeated freeze-thaw cycles should be avoided.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
|Striated Muscle Antibodies, IgG Screen||Less than 1:40|
|Acetylcholine Binding Antibody||0.4 nmol/L or less|
|Acetylcholine Blocking Antibody||26 % blocking or less|
|Titin Antibody||0.45 IV or less|
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
|Acetylcholine Receptor Binding Antibody||Negative
0.5 nmol/L or greater
|Acetylcholine Receptor Blocking Antibody||Negative
42% or greater blocking
|Acetylcholine Receptor Modulating Antibody||Negative
46% or greater modulating
0.72 IV or greater
Analyte Specific Reagent (ASR)
If Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L or Acetylcholine Receptor Blocking Antibody result is greater than 26 percent, then Acetylcholine Receptor Modulating Antibody will be added. If Striated Muscle Ab is detected, then a titer will be added. Additional charges apply.
83519; 83516 x2; 86255; if reflexed, add 83516 and/or 86256
|Component Test Code*||Component Chart Name||LOINC|
|0050747||Striated Muscle Antibodies, IgG Screen||49692-7|
|0080009||Acetylcholine Binding Antibody||11034-6|
|0099580||Acetylcholine Blocking Antibody||42937-3|
- AChR Binding Antibody
- AChR Antibody
- Anti-Skeletal Muscle IgG Antibodies
- Anti-Striated Antibody
- anti-tintin Ab
- Muscle (Skeletal) Antibodies
- Muscle nicotinic Acetylcholine Receptor
- Myasthenia Gravis Antibodies
- Myoid Antibody
- Skeletal Muscle Antibodies
- Striational Antibodies