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Genomic SNP Microarray, Products of Conception
Ordering Recommendation
For use in the context of intrauterine fetal demise or stillbirth when further cytogenetic analysis is desired, pregnancy loss or termination in the presence of fetal anomalies, fetal chromosomal abnormalities that are seen by conventional cytogenetic methods and need further characterization, multiple fetal losses of unknown etiology, or products of conception (POC) specimens that fail to grow in culture.
New York DOH Approval Status
Specimen Required
Thaw media prior to tissue inoculation. Products of conception in a sterile, screw-top container (wide-mouth containers: ARUP supply #42710) filled with tissue culture transport medium (ARUP supply #32788). Available online through eSupply using ARUP Connect or contact ARUP Client Services at 800-522-2787. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, sterile saline, or ringers.
If autopsy is performed: Facia lata, diaphragm, tendon, skin, tissue from internal organs (if fresh), chest wall cartilage (particularly if macerated) or placenta from fetal side.
If no autopsy is performed: Placenta from fetal side is preferred (eg, villi).
Also acceptable: Skin (POC), Cord Tissue, Umbilical cord, Decidua, or Achilles tendon.
Do not place in formalin. Transport products of conception, skin (POC), cord tissue, or decidua (min: 5mg) in sterile, screw-top container filled with tissue transport medium. If specimen size is too large for a normal collection tube, a larger sterile container can be used such as a sterile urine cup and can be flooded with several tubes of cytogenetic tissue media.
Room temperature (fresh tissue or culture flask). Also acceptable: Refrigerated or frozen.
Intact fetus. Specimens preserved in formalin. Autolyzed or contaminated specimens.
Skin (POC), Decidua: formalin fixed.
Cord Tissue: formalin fixed, decomposed.
If specimen collection time is greater than 72 hours, testing may be compromised. The laboratory will make every attempt to culture the specimen. Send specimen to lab for testing.
NOTE: Decidua is acceptable but represents maternal rather than fetal tissue.
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Indefinitely
Methodology
Genomic Microarray (Oligo-SNP Array)
Performed
Sun-Sat
Reported
14-21 days
Reference Interval
Interpretive Data
Refer to report.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Laboratory Developed Test (LDT)
Note
A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up.
This test must be ordered using Cytogenetic test request form #43098 or through your ARUP interface. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65).
Hotline History
Hotline History
CPT Codes
81229
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2005634 | SNP Microarray, Products of Conception | 62375-1 |
Aliases
- oligo-SNP array
- genomic microarray
