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2005545
MPL Mutation Detection by Capillary Electrophoresis
MPL
Ordering Recommendation
May be useful when essential thrombocythemia or idiopathic myelofibrosis is suspected in JAK2 V617F-negative individuals.
New York DOH Approval Status
This test is New York state approved.
Specimen Required
Patient Preparation
Collect
Whole blood or bone marrow in lavender (EDTA).
Specimen Preparation
Whole Blood: Do not freeze. Transport 5 mL whole blood. (Min: 1 mL)
Bone Marrow: Transport 3 mL bone marrow. (Min: 1 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Plasma, serum, FFPE tissue blocks/slides, or frozen tissue. Specimens collected in anticoagulants other than EDTA. Clotted or grossly hemolyzed specimens.
Remarks
Stability
Refrigerated: 7 days; Frozen: Unacceptable
Methodology
Capillary Electrophoresis
Performed
Varies
Reported
7-12 days
Reference Interval
Interpretive Data
Refer to report.
Compliance Category
Laboratory Developed Test (LDT)
Note
The test will detect MPL mutations W515K, W515L, W515A, and S505N.
Hotline History
Hotline History
Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
N/A
CPT Codes
81338
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2005546 | MPL Results | 62948-5 |
| 3016757 | MPL, Source | 31208-2 |
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
- JAK-2 negative MPN diagnosis
- MPL 1p34
- JAK2 V617 negative testing
MPL Mutation Detection by Capillary Electrophoresis
