Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
May be useful when essential thrombocythemia or idiopathic myelofibrosis is suspected in JAK2 V617F-negative individuals.
MnemonicUnique test identifier.
MPL
MethodologyProcess(es) used to perform the test.
Capillary Electrophoresis
PerformedDays of the week the test is performed.
DNA isolation: Sun-Sat Assay: Varies
ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
7-12 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect
Lavender (EDTA) or green (sodium heparin) whole blood or bone marrow.
Specimen Preparation
Whole Blood: Do not freeze. Transport 5 mL whole blood. (Min: 1 mL) Bone Marrow: Transport 3 mL bone marrow. (Min: 1 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Plasma, serum, FFPE tissue blocks/slides, or frozen tissue, DNA extracted by a non-CLIA lab. Specimens collected in anticoagulants other than EDTA or sodium heparin. Clotted or grossly hemolyzed specimens.
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Refer to report
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Compliance Category
Laboratory Developed Test (LDT)
NoteAdditional information related to the test.
The test will detect MPL mutations W515K, W515L, W515A, and S505N.
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.
JAK-2 negative MPN diagnosis
JAK2 V617 negative testing
MPL 1p34
MPL Mutation Detection by Capillary Electrophoresis
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