Ordering Recommendation

• Acceptable single screening test for IgA-deficient individuals with suspected celiac disease. 
• Preferred screening test is Celiac Disease Reflexive Cascade (2008114) or Tissue Transglutaminase (tTG) Antibody, IgG (0056009).  (IgA testing recommended to identify IgA deficiency.)
• May aid in monitoring adherence to gluten-free diet in celiac disease confirmed patients.

Mnemonic

EMA IGG

Methodology

Semi-Quantitative Indirect Fluorescent Antibody

Performed

Tue, Fri

Reported

1-8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Effective November 14, 2011

Less than 1:10

Interpretive Data

The presence of endomysial antibodies IgG, may be useful in identifying IgA-deficient patients at risk for celiac disease. To establish the diagnosis of celiac disease, a positive result must be confirmed through a biopsy of the small intestine.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

86256

Components

Component Test Code* Component Chart Name LOINC
2005502 Endomysial Antibody, IgG 51699-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-Endomysial Antibodies
  • EMA
  • EMA IgG
  • Gluten-Sensitive Enteropathy Tests
  • IgA Deficient Celiac Disease
Endomysial Antibody, IgG