Initial screening for suspected deficiency in the alternative complement pathway.
Semi-Quantitative Radial Immunodiffusion
Serum separator tube or plain red.
Allow specimen to clot for one hour at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube and freeze. (Min: 0.3 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Specimen types other than serum. Refrigerated or room temperature specimens. Specimens left to clot at refrigerated temperature. Specimens exposed to repeated freeze/thaw cycles.
After separation from cells: Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks
Effective April 2, 2012
59 percent normal or greater
This test is intended for screening of functional activity of the alternative pathway of the complement system. Abnormal test results can be due to hereditary absence or acquired functional defect in the activity of any of the individual components of the alternative pathway. If test result is abnormal, order specific tests for evaluation of individual components of alternative pathway, including Complement Factor B (ARUP test code 0051720) and Complement Component 3 (ARUP test code 0050150).
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|2005374||Complement Activity, Alternative Pathway||74520-8|
- Alternate Pathway
- Alternative Complement Pathway
- Alternative Complement Pathway Function
- Alternative Pathway - Complement
- Functional Complement
- Hemolytic Complement