Alternative Complement Pathway Activity (AH50)
Ordering Recommendation
Initial screening for suspected deficiency in the alternative complement pathway.
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
Performed
Sun, Wed
Reported
7-14 days
New York DOH Approval Status
Specimen Required
Plain Red
Allow specimen to clot for one hour at room temperature. Separate serum from cells ASAP and centrifuge at 2-8 degrees C and aliquot serum into ARUP standard transport tube. Freeze specimen immediately at -70 degrees C or lower freezer. (Min: 0.3 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Specimen types other than serum collected from RED TOP tubes. SST or serum gel tubes are not acceptable. Refrigerated or room temperature specimens. Specimens left to clot at refrigerated temperature. Specimens exposed to repeated freeze/thaw cycles. Grossly hemolyzed or grossly lipemic specimens or icteric specimens.
After separation from cells: Ambient: unacceptable; Refrigerated: Unacceptable; Frozen: 30 days if kept at -70 C
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Alternative Complement Pathway Activity | 31 percent normal or greater |
Interpretive Data
See report.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
86161
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2005374 | Alternative Complement Pathway Activity | 74520-8 |
Aliases
- AH50
- Alternate Pathway
- atypical hemolytic uremic syndrome
- C3 glomerulonephrits
- Dense-deposit disease
- Functional Complement
- Hemolytic Complement