Ordering Recommendation

Aids in the diagnosis of systemic lupus erythematosus (SLE).

Mnemonic
CHROMATIN
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon, Wed, Fri

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
19 Units or less Negative
20-60 Units Moderate Positive
61 Units or greater Strong Positive

Interpretive Data

The presence of anti-chromatin antibodies may be useful in the diagnosis of systemic lupus erythematosus (SLE) or drug-induced lupus (DIL) and have been reported to be predictive of lupus nephritis, especially when antibody levels are high.

No compliance statements are in use for this test.

Note
Hotline History
N/A
CPT Codes

83516

Components
Component Test Code* Component Chart Name LOINC
2005288 Chromatin Antibody, IgG 32580-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-Chromatin
  • Anti-DNP
  • Anti-Nucleosome
  • Antichromatin
  • Antinucleosome
  • Chromatin Antibodies
  • chromatin IgG Ab
  • H2A-H2B-H3-H4
  • LE-Cell Factor
  • Nucleosome
Chromatin Antibody, IgG