Ordering Recommendation
Aids in the diagnosis of systemic lupus erythematosus (SLE).
Mnemonic
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed, Fri
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Refrigerated.
Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, icteric, or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
19 Units or less | Negative |
20-60 Units | Moderate Positive |
61 Units or greater | Strong Positive |
Interpretive Data
The presence of anti-chromatin antibodies may be useful in the diagnosis of systemic lupus erythematosus (SLE) or drug-induced lupus (DIL) and have been reported to be predictive of lupus nephritis, especially when antibody levels are high.
FDA
Note
Hotline History
CPT Codes
83516
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2005288 | Chromatin Antibody, IgG | 32580-3 |
Aliases
- Anti-Chromatin
- Anti-DNP
- Anti-Nucleosome
- Antichromatin
- Antinucleosome
- Chromatin Antibodies
- chromatin IgG Ab
- H2A-H2B-H3-H4
- LE-Cell Factor
- Nucleosome