Ordering Recommendation

Aids in the diagnosis of systemic lupus erythematosus (SLE).

Mnemonic
CHROMATIN
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon, Wed, Fri

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Urine or plasma. Contaminated, heat-inactivated, severely hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
19 Units or less Negative
20-60 Units Moderate Positive
61 Units or greater Strong Positive

Interpretive Data

The presence of anti-chromatin antibodies may be useful in the diagnosis of systemic lupus erythematosus (SLE) or drug-induced lupus (DIL) and have been reported to be predictive of lupus nephritis, especially when antibody levels are high.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

83516

Components
Component Test Code* Component Chart Name LOINC
2005288 Chromatin Antibody, IgG 32580-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Anti-Chromatin
  • Anti-DNP
  • Anti-Nucleosome
  • Antichromatin
  • Antinucleosome
  • Chromatin Antibodies
  • chromatin IgG Ab
  • H2A-H2B-H3-H4
  • LE-Cell Factor
  • Nucleosome
Chromatin Antibody, IgG