Ordering Recommendation

Determine antiviral drug resistance to cidofovir, foscarnet sodium, and ganciclovir.


Polymerase Chain Reaction/Sequencing




2-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Lavender (EDTA), pink (K2EDTA) or plasma preparation tube.

Specimen Preparation

Separate plasma from cells within 8 hours. Transfer 4 mL plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Heparinized specimens.


Please submit most recent viral load and test date, if available.


Ambient: 8 hours; Refrigerated: 72 hours; Frozen: 1 month

Reference Interval
Interpretive Data

Codons 457-630 of the UL97 gene and codons 393-1000 of the UL54 gene are sequenced. Mutations associated with resistance to ganciclovir, cidofovir, and foscarnet are reported. Mutations in viral sub-populations below 20 percent of total may not be detected.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.


This test may be unsuccessful if the plasma CMV DNA viral load is less than 1,500 CMV DNA copies per mL of plasma.

Hotline History
CPT Codes


Component Test Code* Component Chart Name LOINC
2004761 CMV Cidofovir Resistance 72856-8
2004762 CMV Foscarnet Resistance 42317-8
2004763 CMV Ganciclovir Resistance 72854-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • CMV
  • CMV Genotype
  • CMV Genotyping
  • CMV Resistance
  • CMV Resistance Genotype
  • CMV Resistance Sequencing
  • CMV Sequencing
  • CMV UL54
  • CMV UL54 Genotype
  • CMV UL97
  • CMV UL97 Genotype
  • CMV UL97/UL54 Genotype
  • Cytomegalovirus Resistance
Cytomegalovirus Antiviral Drug Resistance by Sequencing