Aids in the diagnosis of type I and II leukocyte adhesion deficiency. Panel measures CD11b, CD15, and CD18 on neutrophils.
Semi-Quantitative Flow Cytometry
Green (Sodium or Lithium Heparin).
Transport 5 mL whole blood. (Min: 1 mL) Specimen must be analyzed within 48 hours of collection.
Clotted or hemolyzed specimens.
Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable
Effective August 20, 2012
The Leukocyte Adhesion Deficiency Panel measures the receptors CD11b, CD15, and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
- Beta 2 integrins
- CD11b; CD15; CD18
- LAD I, II determination