Icon

Time Sensitive
Ordering Recommendation

Aids in the diagnosis of type I and II leukocyte adhesion deficiency. Panel measures CD11b, CD15, and CD18 on neutrophils.

Mnemonic
LAD PAN
Methodology

Semi-Quantitative Flow Cytometry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

Green (Sodium or Lithium Heparin).

Specimen Preparation

Transport 5 mL whole blood. (Min: 1 mL) Specimen must be analyzed within 48 hours of collection.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Clotted or hemolyzed specimens.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable

Reference Interval

Effective August 20, 2012

Available Separately
Component
Reference Interval
No %  CD11b 93-100%
No %  CD15 91-100%
No %  CD18 98-100%

Interpretive Data

The Leukocyte Adhesion Deficiency Panel measures the receptors CD11b, CD15, and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported.  Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

86356 x3

Components
Component Test Code* Component Chart Name LOINC
0095818 % CD18 38170-7
0095922 % CD11b 17110-8
0095957 % CD15 20590-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Beta 2 integrins
  • CD11b; CD15; CD18
  • LAD I, II determination
Leukocyte Adhesion Deficiency Panel