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Time Sensitive

Ordering Recommendation

Aids in the diagnosis of type I and II leukocyte adhesion deficiency. Panel measures CD11a, CD11b, CD15s, and CD18 on neutrophils.

Mnemonic

LAD PAN

Methodology

Semi-Quantitative Flow Cytometry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Green (Na-Heparin) or Purple (K-EDTA)..

Specimen Preparation

Transport 5 mL whole blood. (Min: 1 mL) Specimen must be analyzed within 72 hours of collection.

Storage/Transport Temperature

Room temperature or refrigerated.

Unacceptable Conditions

Clotted or hemolyzed specimens. Frozen specimens.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 72 hours; Frozen: Unacceptable.

Reference Interval

Effective November 15, 2021

Available Separately
Separately Component
Reference Interval
No %  CD11a 97-100%
No %  CD11b 96-100%
No %  CD15s 95-100%
No %  CD18 99-100%

Interpretive Data

The Leukocyte Adhesion Deficiency Panel measures the receptors CD11a, CD11b, CD15s, and CD18 normally found on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Decreased values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD11 and CD18 are decreased or absent in leukocyte adhesion deficiency (LAD) type I and CD15s is decreased or absent in LAD type II.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

86356 x4

Components

Component Test Code* Component Chart Name LOINC
0095818 % CD18 17121-5
0095922 % CD11b 17110-8
0095957 % CD15s 17117-3
3004266 % CD11a 17109-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Beta 2 integrins
  • CD11a, CD11b; CD15s; CD18
  • LAD I, II determination
Leukocyte Adhesion Deficiency Panel