Ordering Recommendation

Preferred panel for the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides.

Mnemonic
RA PAN
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Immunoturbidimetry

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Fasting specimen preferred.

Collect

Serum separator tube.

Specimen Preparation

Allow serum to clot completely at room temperature before centrifuging. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) Serum is the only acceptable specimen type for this assay without a disclaimer.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Urine or plasma. Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Reference Interval
Available Separately
Components
Reference Interval
0055256 Cyclic Citrullinated Peptide (CCP) Antibody, IgG
19 Units or less Negative
20-39 Units Weak positive
40-59 Units Moderate positive
60 Units or Greater Strong positive

0050465 Rheumatoid Factor 0-14 IU/mL

Interpretive Data

Anti-cyclic citrullinated peptide (anti-CCP) IgG antibodies are present in about 69-83 percent of patients with rheumatoid arthritis (RA) and have specificities of 93-95 percent. These autoantibodies may be present in the preclinical phase of disease, are associated with future RA development, and may predict radiographic joint destruction. Patients with weak positive results should be monitored and testing repeated.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

86200; 86431

Components
Component Test Code* Component Chart Name LOINC
0050465 Rheumatoid Factor 11572-5
0055256 Cyclic Citrullinated Peptide Ab, IgG 33935-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CCP and RF
  • RA Panel
  • RF and CCP IgG
  • Rheumatoid Arthritis Profile
Rheumatoid Arthritis Panel