Ordering Recommendation
Mnemonic
CORT TMS
Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Wed, Sat

Reported

2-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Specimen should be collected between 8-10 a.m.

Collect

Serum separator tube, lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).

Specimen Preparation

Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions
Remarks
Stability

After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: 6 months

Reference Interval
Adult Reference Ranges for Cortisol, Serum, µg/dL
AM 4.6-20.6 µg/dL
PM 1.8-13.6 µg/dL
Stimulation 30-60  Minutes Post 0.25 mg Cosyntropin IV Greater than 20.0 µg/dL

Pediatric Reference Ranges for Cortisol, Serum, µg/dL
AM
1-12 months 4.6-23.0 µg/dL
1-5 years 6.0-25.0 µg/dL
6-17 years 4.6-15.0 µg/dL
Stimulation 30-60 Minutes Post 0.25 mg Cosyntropin IV
1-12 months 32.0-60.0 µg/dL
1-5 years 22.0-40.0 µg/dL
6-17 years 17.0-28.0 µg/dL

Interpretive Data



Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Codes

82533

Components
Component Test Code* Component Chart Name LOINC
2003251 Cortisol by LC-MS/MS, Serum or Plasma 2143-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Cortisol by LC-MS/MS, Serum or Plasma