Lacosamide, Serum or Plasma

2003182
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High
Normal

Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic

LACOSA SP

Methodology

High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated: Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

Ambient: 15 days; Refrigerated: 15 days; Frozen: 15 days

Reference Interval

Effective November 15, 2021

Therapeutic Range: Not well established. Suggested range 1.0-10.0 µg/mL
Toxic Level Greater than or equal to 20 µg/mL

Interpretive Data

Lacosamide is an anticonvulsant drug indicated for adjunctive therapy for partial-onset seizures. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. Adverse effects may include dizziness, fatigue, nausea, vomiting, blurred vision, and tremor.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/15/2021
X
X
N/A

CPT Codes

80235

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Components

Component Test Code* Component Chart Name LOINC
2003183 Lacosamide, Serum or Plasma 59297-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Lacosamide blood level
  • Vimpat
  • vimpat blood level
Lacosamide, Serum or Plasma