Tapentadol and Metabolite, Urine, Quantitative

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Positive Cutoff:
           Tapentadol: 50 ng/mL
           Tapentadol glucuronide: 100 ng/mL
           Tapentadol-O-sulfate: 100 ng/mL
           N-desmethyltapentadol: 100 ng/mL
                                                   
For medical purposes only; not valid for forensic use.

The presence of metabolite(s) without parent drug is not uncommon and may indicate use over the prior week.

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.