Ordering Recommendation

Preferred test to follow-up presumptive results. For general screening, Tapentadol Urine Screen with Reflex to Quantitation (2012294) is preferred.

Mnemonic

TAPENTA UR

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Mon

Reported

1-8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Random urine.

Specimen Preparation

Transfer 2 mL urine with no additives or preservatives to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Specimens exposed to repeated freeze/thaw cycles.

Remarks
Stability

Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years.

Reference Interval

Effective August 17, 2015

Drugs Covered Cutoff Concentrations
Tapentadol 50 ng/mL
Tapentadol glucuronide 100 ng/mL
Tapentadol-O-sulfate (qualitative only) 100 ng/mL
N-desmethyltapentadol (qualitative only) 100 ng/mL

Interpretive Data

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Positive Cutoff:

           Tapentadol: 50 ng/mL
           Tapentadol glucuronide: 100 ng/mL
           Tapentadol-O-sulfate: 100 ng/mL
           N-desmethyltapentadol: 100 ng/mL
                                                   
For medical purposes only; not valid for forensic use.

The presence of metabolite(s) without parent drug is not uncommon and may indicate use over the prior week.

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80372 (Alt code: G0480)

Components

Component Test Code* Component Chart Name LOINC
2003129 Tapentadol, Urn, Quant 65807-0
2003130 N-desmethyltapentadol, Urn, Qual 89306-5
2005875 Tapentadol glucuronide, Urn, Quant 75362-4
2005879 Tapentadol-O-sulfate, Urn, Qual
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Nucynta
  • Tapentadol, Quantitative, Urine
  • urine tapentadol concentration
Tapentadol and Metabolite, Urine, Quantitative