Ordering Recommendation

Useful for general testing in contexts of compliance and/or abuse. Preferred test to follow-up presumptive results.

Mnemonic
METHPHENUR
Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Mon, Thu, Sat

Reported

1-7 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Random urine.

Specimen Preparation

Transfer 2 mL urine with no additives or preservatives to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Room temperature specimens.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 3 weeks; Frozen: 3 months

Reference Interval
Drugs Covered Methylphenidate
Methylphenidate 10 ng/mL
Ritalinic acid 50 ng/mL

Interpretive Data

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Positive Cutoff:   Methylphenidate: 10 ng/mL
                    Ritalinic acid: 50 ng/mL   
                             
The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80360 (Alt code: G0480)

Components
Component Test Code* Component Chart Name LOINC
2003116 Methylphenidate, Urn, Quant 3809-1
2003117 Ritalinic acid, Urn, Quant 33507-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Attenade
  • Concerta
  • Daytrana
  • Dexmethylphenidate
  • Focalin (Methylphenidate and Metabolite - Confirmation/Quantitation - Urine)
  • Metadate
  • Methylin
  • Methylphenidate
  • Ritalin
  • Ritalinic Acid
  • Urine ritalin concentration
Methylphenidate and Metabolite, Urine, Quantitative