Use with CA 125 to monitor ovarian cancer, usually epithelial subtype, post therapy if pretreatment level was elevated. Not recommended for monitoring known mucinous or germ cell ovarian cancer. Not a stand-alone test for ovarian cancer screening or diagnosis.
Quantitative Electrochemiluminescent Immunoassay
Within 24 hours
New York DOH Approval Status
Serum Separator Tube (SST). Also acceptable: Green (Lithium Heparin), Lavender (K2 EDTA), or Lavender (K3 EDTA).
Allow specimen to clot completely at room temperature. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Grossly hemolyzed specimens.
Ambient: 5 hours; Refrigerated: 48 hours; Frozen: 4 months
Human Epididymis Protein 4 (HE4) is to be used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer. Serial testing for patient HE4 assay values should be used in conjunction with other clinical findings for monitoring ovarian cancer. ARUP uses the Roche Cobas e602 electrochemiluminescent assay. Values obtained with different assay methods should not be used interchangeably.
|Component Test Code*||Component Chart Name||LOINC|
|2003021||Human Epididymis Prot 4||55180-4|
- HE 4
- Human HE4 Antigen