Ordering Recommendation
Use with CA 125 to monitor ovarian cancer, usually epithelial subtype, post therapy if pretreatment level was elevated. Not recommended for monitoring known mucinous or germ cell ovarian cancer. Not a stand-alone test for ovarian cancer screening or diagnosis.
Mnemonic
Methodology
Quantitative Electrochemiluminescent Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST). Also acceptable: Green (Lithium Heparin), Lavender (K2 EDTA), or Lavender (K3 EDTA).
Allow specimen to clot completely at room temperature. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Frozen.
Grossly hemolyzed specimens.
Ambient: 5 hours; Refrigerated: 48 hours; Frozen: 3 months
Reference Interval
0-140 pmol/L
Interpretive Data
The Roche Human Epididymis Protein 4 (HE4) electrochemiluminescent immunoassay was used. Results obtained with different test methods or kits cannot be used interchangeably. The HE4 test is used as an aid in monitoring recurrence or progressive disease in patients with epithelial ovarian cancer. Serial testing for patient HE4 assay values should be used in conjunction with other clinical findings for monitoring ovarian cancer.
FDA
Note
Hotline History
Hotline History
CPT Codes
86305
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2003021 | Human Epididymis Prot 4 | 55180-4 |
Aliases
- HE 4
- HE4
- Human HE4 Antigen