Monoclonal Protein Study, Expanded Panel, Serum

2002715
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Ordering Recommendation

Aids in the diagnosis and monitoring of monoclonal gammopathies. Panel includes serum free light chain testing, eliminating the need for urine monoclonal studies as part of initial screening. Use to detect, quantify, and characterize serum monoclonal protein.

Mnemonic

IFE FLC

Methodology

Qualitative Immunofixation Electrophoresis/Quantitative Capillary Electrophoresis/Quantitative Immunoturbidimetry/Quantitative Spectrophotometry

Performed

Sun-Sat

Reported

1-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2.5 mL serum to an ARUP Standard Transport Tube. (Min: 2.0 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Room temperature specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month

Reference Interval

Test Number
 Components
 Reference Interval
0050640 Protein Electrophoresis, Serum Effective August 19, 2019
Test Number
 Components
 Reference Interval
  Total Protein, Serum Refer to report
  Albumin Refer to report
  Alpha 1 Globulin Refer to report
  Alpha 2 Globulin Refer to report
  Beta Globulin Refer to report
  Gamma Refer to report

0050340 Immunoglobulin A Effective February 16, 2021
0-2 years: 2-126 mg/dL
3-4 years: 14-212 mg/dL
5-9 years: 52-226 mg/dL
10-14 years: 42-345 mg/dL
15-18 years: 60-349 mg/dL
19 years and older: 68-408 mg/dL

0050350 Immunoglobulin G Effective February 16, 2021
0-2 years: 242-1108 mg/dL            
3-4 years: 485-1160 mg/dL
5-9 years: 514-1672 mg/dL     
10-14 years: 581-1652 mg/dL                   
15-18 years: 479-1433 mg/dL                         
19 years and older : 768-1632 mg/dL

0050355 Immunoglobulin M Effective February 16, 2021
0-2 years: 21-215 mg/dL                     
3-4 years: 26-155 mg/dL                                
5-9 years: 26-188 mg/dL                          
10-14 years: 47-252 mg/dL                               
15-18 years: 26-232 mg/dL
19 years and older: 35-263 mg/dL

  Kappa Qnt Free Light Chains Effective February 18, 2020
3.30 - 19.40 mg/L
  Lambda Qnt Free Light Chains Effective February 18, 2020
5.71-26.30 mg/L
  Kappa/Lambda Free Light Chain Ratio 0.26-1.65

Interpretive Data

Undetected antigen excess is a rare event but cannot be excluded. Free light chain results should always be interpreted in conjunction with other clinical and laboratory findings.

Compliance Category

FDA

Note

A copy of the graph will follow the final report.  This assay is highly sensitive to increasing concentrations of monoclonal free kappa or free lambda light chains in the serum of patients with evolving or relapsing myelomas.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/16/2021
X
X
07/06/2020
X
N/A

CPT Codes

82784 x3; 84155; 84165; 86334; 83521 x2

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Components

Component Test Code* Component Chart Name LOINC
0050020 Albumin 2862-1
0050035 Alpha 1 Globulin 2865-4
0050060 Alpha 2 Globulin 2868-8
0050110 Beta Globulin 2871-2
0050270 Gamma 2874-6
0050271 Immunofixation 25700-6
0050340 Immunoglobulin A 2458-8
0050350 Immunoglobulin G 2465-3
0050355 Immunoglobulin M 2472-9
0050545 Total Protein, Serum 2885-2
0055168 Kappa Qnt Free Light Chains 36916-5
0055169 Lambda Qnt Free Light Chains 33944-0
0055179 Kappa/Lambda Free Light Chain Ratio 80517-6
2005168 SPEP/IFE Interpretation 49275-1
2012457 EER Monoclonal Protein and FLC, Serum 11502-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • IFE
  • IgA, IgG, and IgM
  • Immunofixation, serum
  • Kappa Qnt Free Light Chains
  • Kappa/Lambda Free Light Chain Ratio
  • Kappa/Lambda Free Light Chains
  • Lambda Qnt Free Light Chains
  • MGUS study
  • Monoclonal Protein Study
  • Mutiple Myeloma Study
  • SPEP
Monoclonal Protein Study, Expanded Panel, Serum