Gastrointestinal Stromal Tumor Mutation (Change effective as of 11/15/21: Refer to 3004279 in the November Hotline)
Detect activating mutations in KIT and PDGFRA. Predict response to tyrosine kinase inhibitor (TKI) therapy.
Massively Parallel Sequencing
New York DOH Approval Status
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Diff-Quik and Papanicolaou stained cytology smears are also acceptable. Number of slides needed is dependent on the tumor cellularity of the smear. Slide(s) will be destroyed during testing process and will not be returned to client. Protect from excessive heat. Transport block and/or slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.
Resections: Transport 8 unstained 5-micron slides. (Min: 5 slides)
Small Biopsies: Transport 15 unstained 5-micron slides. (Min: 10 slides)
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.
Less than 10 percent tumor. Specimens fixed/processed in heavy metal fixatives. Decalcified specimens. FNA smears with less than 50 tumor cells.
Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Refer to report
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
A full list of the targeted genes and regions is listed in the Additional Technical Information.
88381; 81272; 81314
|Component Test Code*||Component Chart Name||LOINC|
- c-kit Mutation Analysis in Gastrointestinal Stromal Tumors (GISTs)
- CD117 KIT
- GIST Mutation
- KIT exons 9, 11, 13, 14, 17, and 18
- KIT mutation
- PDGFRA exons 12, 14 and 18
- PDGFRA Mutation in Gastrointestinal Stromal Tumors (GISTs)
- TKI resistance
- TKI sensitivity