Screen and diagnose hyperaldosteronism.
Quantitative Chemiluminescent Immunoassay/Quantitative Immunoradiometry
Collect midmorning after patient has been sitting, standing or walking for at least 2 hours and seated for 5-15 minutes. Refer to the Additional Technical Information for specific patient preparation recommendations.
Serum Separator Tube (SST) AND Lavender (EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes.
Separate from cells ASAP or within 2 hours of collection.
Serum: Transfer 1 mL serum to an ARUP Standard Transport Tube (Min: 0.5mL)
Plasma: Transfer 2 mL EDTA plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL)
Both specimens should be collected and submitted together for testing.
Serum: Frozen. Also acceptable: Refrigerated.
Plasma: CRITICAL FROZEN. Separate specimens must be submitted when additional tests are ordered.
Plasma collected in citrate, heparin, or oxalate. Hemolyzed specimens.
Serum: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 1 month
Plasma: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 1 month
|0070015||Aldosterone, Serum||Effective May 16, 2011
|2001575||Renin, Direct||2.5-45.7 pg/mL|
|Aldosterone/Direct Renin Calculation||0.1-3.7
An Aldosterone/Direct Renin Ratio of greater than 3.7 is suggestive of hyperaldosteronism.
Normal serum levels of aldosterone are dependent on the sodium intake and whether the patient is upright or supine. High sodium intake will tend to suppress serum aldosterone, whereas low sodium intake will elevate serum aldosterone. The reference intervals for serum aldosterone are based on normal sodium intake.
Do not use this test for patients treated with Cathepsin B. Menstruating females and those taking estrogen containing medications may have lower renin direct concentrations, resulting in falsely high aldosterone-renin ratio (ARR). In these cases, order Aldosterone/Renin Activity Ratio (ARUP Test code 0070073). Refer to the Additional Technical Information for Endocrine Society recommendations for patient preparation, specimen collection, medications for hypertension control during confirmatory testing for primary aldosteronism, and factors that may lead to false-positive or false-negative ARR results.
|Component Test Code*||Component Chart Name||LOINC|
|2002583||Aldosterone/Direct Renin Calculation||30894-0|
- Aldosterone and Direct renin
- aldosterone serum
- aldosterone/direct renin calculation
- Aldosterone/Renin Ratio
- Renin direct