Pancreatobiliary FISH

2002528
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Example Reports
Negative
Positive

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Specimen Collection and Handling

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Patient History for Non-Gynecologic Cytopathology Testing

Ordering Recommendation

Detect aneuploidy for chromosomes 3, 7, and 17. Use in conjunction with current standard diagnostic procedures as an aid for diagnosis of pancreatic cancer.

Mnemonic

PF REQUEST

Methodology

Fluorescence in situ Hybridization (FISH)/Computer Assisted Analysis/Microscopy

Performed

Mon-Fri

Reported

4-12 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Bile or pancreatic duct brushings, biliary stent, or fine needle aspirates of the pancreas in UroVysion FISH Collection Kit (ARUP Supply #41440) available online through eSupply using ARUP Connector contact Client Services at (800) 522-2787. For specific instructions refer to Specimen Collection & Handling.

Specimen Preparation

Place specimen in Cytolyt or PreservCyt fixative vial. If the specimen is a brushing, submit the brush in the fixative. Specimen should be placed in fixative vial immediately after collection.

Storage/Transport Temperature

Ambient or Refrigerated.

Unacceptable Conditions

Frozen specimens. Unfixed specimens not collected in Cytolyt or PreservCyt fixative. Specimens submitted in expired collection vials.

Remarks

Specimen source is required.

Stability

Ambient: 1 week from collection; Refrigerated: 1 week from collection; Frozen: Unacceptable

Reference Interval

Positive ≥5 cells with gains of two or more chromosomes are present
Equivocal Tetrasomy Cells present with tetrasomic or near tetrasomic signal patterns
Equivocal Trisomy ≥10 cells with gains of a single chromosome, (Trisomy 7 or Trisomy 3)
Negative < 5 abnormal cells are present

Interpretive Data

Refer to Report.

Compliance Category

Laboratory Developed Test (LDT)

Note

The UroVysion Kit (ARUP Supply #41440) is designed to detect aneuploidy for chromosomes 3, 7 and 17via fluorescence in situ hybridization (FISH). Results of this test must be interpreted in conjunction with clinical evidence and other laboratory testing and should not be used alone,as a diagnosis of pancreatobiliary carcinoma.

Hotline History

N/A

CPT Codes

88366 

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Components

Component Test Code* Component Chart Name LOINC
2002452 Pancreatobiliary FISH Specimen Source 66746-9
2002458 Fixative
2002459 Pancreatobiliary FISH Clinical History 22636-5
2002463 Pancreatobiliary FISH Gross Description 22634-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Bile Duct FISH
  • Bile Duct Tumor
  • Biliary Tract Malignancy FISH
  • Cholangiocarcinoma FISH
  • Cytology
  • FISH
  • Pancreas FISH
Pancreatobiliary FISH