Pancreatobiliary FISH

NEGATIVE results indicate a lack of evidence for the presence of numeric chromosomal abnormalities commonly associated with pancreatobiliary cancer within the cells collected in this specimen. Negative results in the presence of other symptoms/signs of pancreatobiliary carcinoma may suggest the possibility of a false negative test. In this circumstance, additional clinical studies to exclude pancreatobiliary carcinoma should be pursued, as clinically indicated.
Although this test was designed to detect genetic abnormality associated with most pancreatobiliary cancers, there will be some pancreatobiliary cancers whose genetic changes cannot be detected by this test.

POSITIVE results indicate the presence of one or more numeric chromosomal abnormalities commonly associated with pancreatobiliary carcinoma or other pancreatic malignancy from another site (bile or pancreatic duct brushings, biliary stent, orfi ne needle aspirates of the pancreas) within the cells collected in this specimen. Positive results in the absence of clinical documentation may require further clinical evaluation to exclude these as a source of the abnormal cells is justified.
UroVysion Bladder Cancer Kit probes were used to detect aneuploidy for chromosomes 3, 7, and 17 via fluorescence in situ hybridization (FISH). Results from this test are intended for use in conjunction with, and not in lieu of, current standard diagnostic proceduresas an aid for initial diagnosis of pancreatobiliary carcinoma or related sources.