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Cryoglobulin, Qualitative with Reflex to IFE Typing and Quantitative IgA, IgG, and IgM
Ordering Recommendation
Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.
New York DOH Approval Status
Specimen Required
Fasting specimen required: Overnight or minimum of 8 hours fasting.
Whole blood drawn in a prewarmed (37°C) syringe. Specimen may be drawn directly into a prewarmed plain red.
Maintain whole blood at 37°C until clotting is complete; do not refrigerate or freeze at any time. Immediately after blood has been obtained, transfer specimen to a prewarmed plain red (if not used for collection). Separate serum from cells using a 37°C centrifuge, if possible. Transfer 3 mL serum to an ARUP standard transport tube. (Min: 3 mL)
Room temperature. Also acceptable: Refrigerated.
Plasma. Serum separator tubes. Grossly hemolyzed or lipemic specimens.
Proper collection and transport of specimen is critical to the outcome of the test. Quantities less than 3 mL may affect the sensitivity of the test.
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable
Methodology
Qualitative Cold Precipitation/Qualitative Immunofixation Electrophoresis (IFE)/Qualitative Nephelometry
Performed
Sun-Sat
Reported
3-5 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Cryoglobulin, Qualitative | Negative at 72 hours. |
Interpretive Data
Laboratory Developed Test (LDT)
Note
If Cryoglobulin Qualitative is positive, then Immunofixation Electrophoresis Typing and Quantitative IgA, IgG and IgM will be added. Additional charges apply.
Hotline History
CPT Codes
82595; if reflexed, add 82784 x3; 86334
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050185 | Cryoglobulin, Qualitative | 5117-7 |
Aliases
- Cryoglobulins reflex test to IFE
- Cryoglobulins/cryoglobulins
- Cryoprotein
- Quantitative cryoglobulins
