Ordering Recommendation

Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.




Qualitative Cold Precipitation/Qualitative Immunofixation Electrophoresis/Quantitative Nephelometry




3-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Fasting specimen required.


Whole blood drawn in a pre-warmed (37°C) syringe. Specimen may be drawn directly into a pre-warmed plain red.

Specimen Preparation

Maintain whole blood at 37°C until clotting is complete; do not refrigerate or freeze at any time. Immediately after blood has been obtained, transfer specimen to a pre-warmed plain red (if not used for collection). Separate serum from cells using a 37°C centrifuge, if possible. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 3 mL)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated.

Unacceptable Conditions

Plasma. Serum separator tubes. Grossly hemolyzed or lipemic specimens.


Proper collection and transport of specimen is critical to the outcome of the test. Quantities less than 3 mL may affect the sensitivity of the test.


After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

Test Number
Reference Interval
  Cryoglobulin, Qualitative Negative at 72 hours.

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


If Cryoglobulin Qualitative is positive, then Immunofixation Electrophoresis Typing and Quantitative IgA, IgG and IgM will be added. Additional charges apply.

Hotline History


CPT Codes

82595; if reflexed, add 82784 x3; 86334


Component Test Code* Component Chart Name LOINC
0050185 Cryoglobulin, Qualitative 5117-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Cryoglobulins reflex test to IFE
  • Cryoglobulins/cryoglobulins
  • Cryoprotein
  • Quantitative cryoglobulins
Cryoglobulin, Qualitative with Reflex to IFE Typing and Quantitative IgA, IgG, and IgM