Time Sensitive


Oncology Test Request Form Recommended (ARUP form #43099)
Ordering Recommendation

Aid in diagnosis and classification of hematopoietic neoplasms presenting with prominent eosinophilia. Does not detect rearrangements associated with chronic myelogenous leukemia.


Fluorescence in situ Hybridization (FISH)




3-10 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Non-diluted bone marrow aspirate collected in a heparinized syringe. Also acceptable: Green (Sodium Heparin).

Specimen Preparation

Bone Marrow: Transfer 3 mL bone marrow to a Green (Sodium Heparin) (Min: 1 mL).
Whole Blood: Transport 5 mL whole blood. (Min: 2 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Paraffin-embedded specimens. Clotted specimens.


Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Probes included: PDGFR-alpha,  PDGFR-beta, FGFR1, and CBFB.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.


A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.

Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.

Hotline History
CPT Codes

88271 x4; 88275 x4; 88291

Component Test Code* Component Chart Name LOINC
2002379 Eosinophilia Panel by FISH
2002380 EER FISH EOS P
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • FISH, Myeloproliferative Neoplasms (Eosinophilia)
Eosinophilia Panel by FISH