Time Sensitive


Cytogenetic Test Request Form Recommended (ARUP form #43098)

Ordering Recommendation

Diagnostic test to identify genomic abnormalities (eg, aneuploidy and microdeletions). Performed on direct or cultured amniotic fluid and chorionic villus sampling (CVS) specimens.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation

Fetal Specimen: Amniotic fluid OR chorionic villi in cytogenetic tissue media (ARUP Supply #32788). If cytogenetic tissue media is not available, collect in plain RPMI, Hanks solution, saline, or ringers.
New York State Clients: Discard first 2 mL of fluid aspirated to avoid maternal cell contamination.

Specimen Preparation

Do not freeze specimen or expose to extreme temperatures. Do not place in formalin. Transport 15-30 mL amniotic fluid in a sterile container OR 5-20 mg CVS in a sterile, screw-top container filled with tissue culture transport medium.
New York State Clients: Specimen is collected in a 20 mL sterile syringe and transferred aseptically to sterile tubes. Specimen must be received at performing laboratory within 48 hours of collection. For specimen requirements and direct submission instructions please contact ARUP Referral Testing at 800-242-2787 ext. 5145.

Storage/Transport Temperature

Room temperature (all specimens) received in 48 hours.

Unacceptable Conditions

Frozen or fixed specimens.


New York State Clients: Must submit specimen with Labcorp's Informed Consent and Prenatal Chromosome SNP Microarray Questionnaire


All specimen types: Ambient: 48 hours; Refrigerated: 48 hours Acceptable; Frozen: Unacceptable


Genomic Microarray (Oligo-SNP Array)




7-21 days

Reference Interval

By report

Interpretive Data

See report.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)


Maternal Cell Contamination: Maternal cell contamination studies recommended. For array AND amniotic fluid chromosomes, also order Chromosome Analysis, Amniotic fluid (ARUP test code 2002293). For array AND CVS chromosomes, also order Chromosome Analysis, Chorionic Villus (ARUP test code 2002291). For maternal cell contamination studies or if submitting maternal blood, order Maternal Cell Contamination, Maternal Specimen (ARUP test code 0050608) accompanied by a test request form for the mother (this test is performed at no charge). For questions regarding ordering please contact ARUP's genetic counselor at 800-242-2787 ext. 2141.

A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.

Turnaround times may be delayed if specimens are suboptimal or culturing is required prior to testing.

This test must be ordered using Cytogenetic test request form 43098 or through your ARUP interface. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65).

Hotline History


CPT Codes

81229; 81265 Fetal Cell Contamination (FCC)


Component Test Code* Component Chart Name LOINC
0050548 Maternal Contamination Study Fetal Spec 59266-7
2002368 Cytogenomic SNP Microarray - Fetal 62356-1
2002523 Maternal Specimen 8251-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Array CGH
  • Comparative Genomic Hybridization
  • Microarray Genomic, Fetal
  • Oligo Array
Cytogenomic SNP Microarray - Fetal