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Time Sensitive

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Oncology Test Request Form Recommended (ARUP form #43099)
Ordering Recommendation

Limited role in the workup of myeloproliferative neoplasms in the setting of an otherwise optimal cytogenetic study. Aids in exclusion of cryptic BCR-ABL1 rearrangement in chronic myelogenous leukemia and in the exclusion of a PDGFRA abnormality in cases of neoplastic eosinophilia. 

Mnemonic
FISH MPD P
Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Sun-Sat

Reported

3-10 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).

Specimen Preparation

Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Frozen specimens. Paraffin-embedded specimens. Clotted specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Probes included: BCR/ABL, PDGFR-alpha,  PDGFR-beta, and, FGFR1.

Compliance Category

Analyte Specific Reagent (ASR)

Note

A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.

Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

If cell pellets or dropped cytogenetics slides are not submitted, a processing fee will apply.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.

Hotline History
N/A
CPT Codes

88271 x4; 88275 x4; 88291

Components
Component Test Code* Component Chart Name LOINC
2002361 MPD Panel by FISH
2002362 EER FISH MPD P
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Myeloproliferative Disorders Panel by FISH