Rapid detection of aneuploidy involving chromosomes X, Y, 13, 18, and 21. Assay offered in conjunction with chromosome study.
Fluorescence in situ Hybridization (FISH)
New York DOH Approval Status
Do not freeze or expose to extreme temperatures. Transport 30 mL amniotic fluid in sterile centrifuge tubes. (Min: 15 mL)
Frozen specimens. Bloody specimens.
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Refer to report.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Fluorescence in situ hybridization (FISH) is performed for aneuploidy of chromosomes X, Y, 13, 18, and 21.
The FISH analysis does not detect structural chromosome abnormalities, mosaicism, and other numerical chromosome abnormalities (excluding X, Y, 13, 18, and 21). In addition, false-positive or negative results, as well as maternal cell contamination, have been demonstrated in prenatal FISH analysis. The American College of Medical Genetics recommends that irreversible therapeutic action should not be initiated on the basis of FISH results alone.
A processing fee will be charged if this procedure is canceled at the client's request after the test has been set up or if the sample integrity is inadequate to allow culture growth.
Performance of FISH testing in conjunction with routine cytogenetic analysis is recommended.
This test must be ordered using Cytogenetic test request form #43098 or through your ARUP interface. Specimen and completed test request form, including clinical indication, must be received within 48 hours of collection. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65).
88271 x5; 88275 x5
|Component Test Code*||Component Chart Name||LOINC|
|0097779||Chromosome FISH, Prenatal||55192-9|
|2002211||EER Chromosome FISH, Prenatal|
- AF, amniotic fluid, Insight, PN FISH
- Common trisomy FISH panel
- prenatal FISH