Time Sensitive


Cytogenetic Test Request Form Recommended (ARUP form #43098)

Ordering Recommendation

Rapid detection of aneuploidy involving chromosomes X, Y, 13, 18, and 21. Assay offered in conjunction with chromosome study.

New York DOH Approval Status

This test is not New York state approved. There are no New York state-approved laboratories available. Submit a Non-Permitted Laboratory Request Form (NPL) to the NYDOH prior to collection of specimen. If NPL is approved by NYDOH, and sample is received at ARUP, testing will be performed.

Specimen Required

Patient Preparation

Amniotic fluid.

Specimen Preparation

Do not freeze or expose to extreme temperatures. Transport 30 mL amniotic fluid in sterile centrifuge tubes. (Min: 15 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Frozen specimens. Bloody specimens.


Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable


Fluorescence in situ Hybridization (FISH)




1-3 days

Reference Interval

By report

Interpretive Data

Refer to report.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)


Fluorescence in situ hybridization (FISH) is performed for aneuploidy of chromosomes X, Y, 13, 18, and 21.

The FISH analysis does not detect structural chromosome abnormalities, mosaicism, and other numerical chromosome abnormalities (excluding X, Y, 13, 18, and 21). In addition, false-positive or negative results, as well as maternal cell contamination, have been demonstrated in prenatal FISH analysis. The American College of Medical Genetics recommends that irreversible therapeutic action should not be initiated on the basis of FISH results alone.

A processing fee will be charged if this procedure is canceled at the client's request after the test has been set up or if the sample integrity is inadequate to allow culture growth.

Performance of FISH testing in conjunction with routine cytogenetic analysis is recommended.

This test must be ordered using Cytogenetic test request form #43098 or through your ARUP interface. Specimen and completed test request form, including clinical indication, must be received within 48 hours of collection. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65).

Hotline History


CPT Codes

88271 x5; 88275 x5


Component Test Code* Component Chart Name LOINC
0097779 Chromosome FISH, Prenatal 55192-9
2002211 EER Chromosome FISH, Prenatal 11502-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • AF, amniotic fluid, Insight, PN FISH
  • Common trisomy FISH panel
  • prenatal FISH
Chromosome FISH, Prenatal