Oncology Test Request Form Recommended (ARUP form #43099)
Ordering Recommendation

Alternate test to detect prognostically important genomic abnormalities in CLL.


Fluorescence in situ Hybridization (FISH)




3-10 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Green (sodium heparin). Also acceptable: Non-diluted bone marrow aspirate collected in a heparinized syringe.

Specimen Preparation

Transport 5 mL whole blood (Min: 2 mL). OR Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Frozen specimens. Paraffin-embedded specimens. Clotted specimens.


Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable.

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.


Fluorescence in situ Hybridization panel is performed for CLL prognosis-specific genomic abnormalities as follows: ATM deletion, D13S319 deletion, Trisomy 12, TP53 deletion.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth

If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.

Hotline History
CPT Codes

88271 x4; 88275 x4; 88291

Component Test Code* Component Chart Name LOINC
0092616 Chromosome FISH, CLL Panel 57802-1
2002197 EER Chromosome FISH, CLL Panel 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • 'Chronic Lymphocytic Leukemia FISH Panel
Chromosome FISH, CLL Panel