Time Sensitive


Oncology Test Request Form Recommended (ARUP form #43099)

Ordering Recommendation

Alternate test to detect prognostically important genomic abnormalities in CLL.


Fluorescence in situ Hybridization (FISH)




3-10 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Green (sodium heparin). Also acceptable: Non-diluted bone marrow aspirate collected in a heparinized syringe.

Specimen Preparation

Transport 5 mL whole blood (Min: 2 mL). OR Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Frozen specimens. Paraffin-embedded specimens. Clotted specimens.


Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable.

Reference Interval

By report

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Analyte Specific Reagent (ASR)


Fluorescence in situ Hybridization panel is performed for CLL prognosis-specific genomic abnormalities as follows: ATM deletion, D13S319 deletion, Trisomy 12, TP53 deletion.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth

If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.

This test must be ordered using Oncology test request form #43099 or through your ARUP interface.

Hotline History


CPT Codes

88271 x4; 88275 x4


Component Test Code* Component Chart Name LOINC
0092616 Chromosome FISH, CLL Panel 57802-1
2002197 EER Chromosome FISH, CLL Panel 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • 'Chronic Lymphocytic Leukemia FISH Panel
Chromosome FISH, CLL Panel