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Chromosome Analysis, Chorionic Villus

CHR CVS
Example Reports
Abnormal
Enhanced Report
Normal

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Time Sensitive

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Cytogenetic Test Request Form Recommended (ARUP form #43098)

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Prenatal Cytogenetics Patient History Form

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Informed Consent for Genetic Testing (Required for NY patients)

Ordering Recommendation

Prenatal chromosome analysis on chorionic villi when individual:

  • Is at increased risk for fetal aneuploidy based on maternal age, abnormal noninvasive prenatal testing (NIPT), abnormal multiple marker screening, or abnormal fetal ultrasound.
  • Has a family history of chromosome abnormality or genetic disorder.
  • Desires diagnostic testing instead of screening.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Thaw media prior to collection.

Specimen Preparation

DO NOT FREEZE. Do not place in formalin. Transport chorionic villus (CVS) specimen in a sterile, screw-top container filled with tissue culture transport medium.

Storage/Transport Temperature

Room temperature

Unacceptable Conditions

Frozen specimens. Specimens preserved in formalin.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Methodology

Giemsa Band

Performed

Sun-Sat

Reported

7-14 days

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

These studies involve culturing of living cells; therefore, turnaround times given represent average times, which are subject to multiple variables.

A processing fee to cover sex confirmation and rule out maternal contamination by FISH is added to all Chromosome Analysis, Chorionic Villus Sampling (CVS) tests. An additional processing fee will be charged if this procedure is canceled at the client's request after the test has been set up or if the specimen integrity is inadequate to allow culture growth.

Chorionic villus in a sterile, screw-top container filled with tissue culture transport medium (ARUP Supply #32788). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, saline, or ringers.

If specimen size is too large for a normal collection tube, a larger sterile container can be used such as a sterile urine cup and can be flooded with several tubes of cytogenetic tissue media.

This test must be ordered using Cytogenetic test request form #43098 or through your ARUP interface. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65).

Hotline History

N/A

CPT Codes

88267; 88235

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Components

Component Test Code* Component Chart Name LOINC
0097610 Chromosome Analysis, Chorionic Villus 33774-1
2002201 EER Chromosome Analysis Chorionic Villus 11502-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • chorionic villi
  • Karyotype, CVS
  • NIPS confirmation study
  • NIPT confirmation study
  • Prenatal Chromosomes, CVS
  • Prenatal Diagnosis, CVS, Chromosome Analysis
  • villi
Chromosome Analysis, Chorionic Villus