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Chromosome Analysis, Products of Conception
Ordering Recommendation
Order for standard chromosome analysis performed on cultured fetal or placental cells.
New York DOH Approval Status
Specimen Required
Thaw media prior to tissue inoculation. Products of conception in a sterile, screw-top container (Wide mouth containers: ARUP supply #42710) filled with tissue culture transport medium (ARUP Supply # 32788). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. If cytogenetics tissue media is not available, collect in plain RPMI, Hanks solution, sterile saline, or ringers.
If autopsy is performed: Facia lata, diaphragm, tendon, skin, tissue from internal organs (if fresh), chest wall cartilage (particularly if macerated) or placenta from fetal side.
If no autopsy is performed: Placenta from fetal side is preferred (e.g. villi).
Also acceptable: Umbilical cord or achilles tendon.
DO NOT FREEZE. Do not place in formalin. Transport products of conception (Min: 5 mg) in sterile, screw-top container filled with tissue transport medium. If specimen size is too large for a normal collection tube, a larger sterile container can be used such as a sterile urine cup and can be flooded with several tubes of cytogenetic tissue media.
Room temperature (fresh tissue or culture flask). Also acceptable: Refrigerated.
Frozen specimens. Intact fetus. Specimens preserved in formalin. Specimens consisting of maternal tissue (decidua) only. Autolyzed or contaminated specimens.
If specimen collection time is greater than 72 hours, testing may be compromised. The laboratory will make every attempt to culture the specimen. Send specimen to lab for testing.
Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Methodology
Giemsa Band
Performed
Sun-Sat
Reported
14-28 days
Reference Interval
Interpretive Data
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Counseling and informed consent are recommended for genetic testing. Consent forms are available online.
Laboratory Developed Test (LDT)
Note
These studies involve culturing of living cells; therefore, turnaround times given represent average times, which are subject to multiple variables.
A processing fee will be charged if this procedure is canceled at the client's request after the test has been set up or if the specimen integrity is inadequate to allow culture growth.
This test must be ordered using Cytogenetic test request form #43098 or through your ARUP interface. Please submit the Patient History for Prenatal Cytogenetics form with the electronic packing list (https://ltd.aruplab.com/Tests/Pdf/65).
Hotline History
CPT Codes
88262; 88233
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0097645 | Chromosome Analysis, Prod Concp | 48819-7 |
| 2002206 | EER Chromosome Analysis, Prod Concp | 11526-1 |
Aliases
- Autopsy (ONLY if Chromosomes are indicated)
- Chromosome Analysis, Stillbirth or Miscarriage
- intrauterine fetal demise
- IUFD
- Karyotype
- Karyotype, Stillbirth or Miscarriage
- Miscarriage
- missed abortion
- Pregnancy loss
- SAB
- Spontaneous abortion
- Stillbirth
