Ordering Recommendation

B-Type Natriuretic Peptide (0030191) or proBrain Natriuretic Peptide, NT (0050083) are preferred tests for diagnosis, prognosis, and management of acute and chronic heart failure. ST2 aids in prognostication in patients with acute and chronic heart failure.




Quantitative Enzyme Immunoassay


Tue, Fri


1-8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Serum Separator Tube (SST), Plain Red, Lavender (EDTA), Pink (K2EDTA), or Green (Sodium or Lithium Heparin).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transport 1 mL serum or plasma in an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature


Unacceptable Conditions

Citrated plasma. Grossly hemolyzed or severely lipemic specimens.


After separation from cells: Ambient: 48 hours; Refrigerated: 10 days; Frozen: 18 months

Reference Interval

Males 10.4-52.1 ng/mL
Females 8.4-33.6 ng/mL

Interpretive Data

The Presage ST2 test is an enzyme-linked immunosorbent assay that quantifies soluble ST2 in serum or plasma. ST2 is a member of the interleukin-1 (IL-1) receptor family and is secreted by cardiac muscle cells under conditions of mechanical stress. In individuals with acute myocardial infarction, an increased concentration of soluble ST2 is associated with an increased risk of mortality or heart failure. In individuals with heart failure, an increased concentration of soluble ST2 is strongly associated with the severity of disease, and is a strong predictive indicator of a 1-year mortality that is independent from but additive to that of NT-proBNP.

Compliance Category



Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
2002268 ST2, Soluble 55927-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • ST2
ST2, Soluble