Ordering Recommendation

Use to detect and subtype protein S deficiency. Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 2 mL platelet-poor plasma to an ARUP standard transport tube. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 3 months

Methodology

Microlatex Particle-Mediated Immunoassay

Performed

Mon-Sat

Reported

1-4 days

Reference Interval

Test Number
Components
Reference Interval
  Protein S Ag Free
Age Male (%) Female (%)
1-89 days 15-55 15-55
90-179 days 35-92 35-92
180-364 days 45-115 45-115
1-5 years 62-120 62-120
6-9 years 62-130 62-130
10-17 years 60-140 60-140
18 years and older 74-147 55-123

Interpretive Data

Refer to report

Compliance Category

FDA

Note

If low Protein S Free Antigen is detected, then Protein S, Total Antigen, will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

85306; if reflexed, add 85305

Components

Component Test Code* Component Chart Name LOINC
0098894 Protein S Ag Free 27821-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Protein S Profile
  • Protein S, Free and Total Antigen
Protein S, Free Antigen with Reflex to Protein S, Total Antigen