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Protein S, Free Antigen with Reflex to Protein S, Total Antigen
Ordering Recommendation
Use to detect and subtype protein S deficiency. Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Methodology
Microlatex Particle-Mediated Immunoassay
Performed
Mon-Sat
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transfer 2 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum. EDTA plasma, clotted or hemolyzed specimens.
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months
Reference Interval
1-89 days: 15-55%
90-179 days: 35-92%
180-364 days: 45-115%
1-5 years: 62-120%
6-9 years: 62-130%
10-17 years: 60-140%
18 years and older Male: 74-147%
18 years and older Female: 55-123%
Interpretive Data
Patients on warfarin may have decreased free protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of free protein S levels. Decreased levels of free protein S are also associated with DIC, liver disease, pregnancy, and inflammatory syndromes.
FDA
Note
If low Protein S Free Antigen is detected, then Protein S, Total Antigen, will be added. Additional charges apply.
Hotline History
CPT Codes
85306; if reflexed, add 85305
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0098894 | Protein S Ag Free | 27821-8 |
Aliases
- Protein S Profile
- Protein S, Free and Total Antigen
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