Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
Aid in the diagnosis and management of monoclonal gammopathies. Use to detect and quantify serum monoclonal protein. Immunofixation is performed if patterns observed in protein electrophoresis p are monoclonal or suspicious.
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Serum protein electrophoresis, when used as a screening test, is useful in the detection of various pathophysiologic states such as inflammation, protein loss, gammopathies, and other dysproteinemias. However, immunofixation electrophoresis (IFE) is a more sensitive technique for the identification of small M-proteins found in patients with amyloidosis, early or treated myeloma or macroglobulinemia, solitary plasmacytoma, or extramedullary plasmacytoma. .
Compliance Category
FDA
NoteAdditional information related to the test.
If patterns from serum protein electrophoresis are monoclonal or suspicious, then Immunofixation Electrophoresis will be added. Additional charges apply.
No additional testing will be added for proteins that are normal, polyclonal, or that lack monoclonal patterns.
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
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AliasesOther names that describe the test. Synonyms.
Electrophoresis, Protein, Serum with Reflex to Immunofixation Electrophoresis
IFE Reflex
MGUS study
Monoclonal protein detection
Monoclonal Protein Study
Multiple Myeloma Study
Protein Electrophoresis with Interpretation, Serum and Reflex to IFE and QNTIG's
Protein Electrophoresis, Serum with Reflex to IFE, Serum
Protein Electrophoresis, with Interpretation Serum, With Reflex to IFE, Serum
SPEP
Protein Electrophoresis with Reflex to Immunofixation, Serum