Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.
Qualitative Cold Precipitation/Quantitative Nephelometry
Fasting specimen required.
Plain red tube.
1) Draw approximately 7 mL of blood into a pre-warmed (37 degrees C) plain red tube. Alternatively: draw into a pre-warmed (37 degrees C) syringe and immediately transfer blood to a pre-warmed (37 degrees C) plain red tube. 2) Maintain collected blood at 37 degrees C until clotting is complete (up to 1 hour). 3) Separate serum from cells ASAP. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks.
Room temperature. Also acceptable: Refrigerated.
Plasma. Serum separator tubes (SST or other clot-activating tubes). Grossly hemolyzed or lipemic specimens.
Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.
After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable
|0050185||Cryoglobulin, Qualitative||Negative at 72 hours.|
|Immunoglobulin A, Cryoprecipitate||0 mg/dL|
|Immunoglobulin G, Cryoprecipitate||0 mg/dL|
|Immunoglobulin M, Cryoprecipitate||0 mg/dL|
The sample is examined daily for the presence or absence of cryoglobulin.
Laboratory Developed Test (LDT)
Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease.
If after three days cryoprecipitate is observed, then quantitative immunoglobulins (IgA, IgG, and IgM) will be added. Additional charges apply.
82595; if reflexed, add 82784 x3
|Component Test Code*||Component Chart Name||LOINC|
|0050188||Cryoglobulin Qualitative Screen||12203-6|
- Cryoglobulins reflex test to IgA, IgG, and IgM
- Quantitative cryoglobulins