Cryoglobulin, Qualitative, with Reflex to Quantitative IgA, IgG, and IgM

2002063
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Example Reports
High
Normal
Ordering Recommendation

Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.

Mnemonic
CRYGB QNT
Methodology

Qualitative Cold Precipitation/Quantitative Nephelometry

Performed

Sun-Sat

Reported

3-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Fasting specimen required.

Collect

Plain red tube.

Specimen Preparation

1) Draw approximately 7 mL of blood into a pre-warmed (37 degrees C) plain red tube. Alternatively: draw into a pre-warmed (37 degrees C) syringe and immediately transfer blood to a pre-warmed (37 degrees C) plain red tube. 2) Maintain collected blood at 37 degrees C until clotting is complete (up to 1 hour).  3) Separate serum from cells ASAP. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated.

Unacceptable Conditions

Plasma. Serum separator tubes (SST or other clot-activating tubes). Grossly hemolyzed or lipemic specimens.

Remarks

Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.

Stability

After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval
Test Number
 Components
 Reference Interval
0050185 Cryoglobulin, Qualitative Negative at 72 hours.
  Immunoglobulin A, Cryoprecipitate 0 mg/dL
  Immunoglobulin G, Cryoprecipitate 0 mg/dL
  Immunoglobulin M, Cryoprecipitate 0 mg/dL

Interpretive Data

The sample is examined daily for the presence or absence of cryoglobulin.  

Compliance Category

Laboratory Developed Test (LDT)

Note

Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease.

If after three days cryoprecipitate is observed, then quantitative immunoglobulins (IgA, IgG, and IgM) will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

82595; if reflexed, add 82784 x3

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Components
Component Test Code* Component Chart Name LOINC
0050188 Cryoglobulin Qualitative Screen 12203-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cryoglobulins/cryoglobulins
  • Cryoglobulins reflex test to IgA, IgG, and IgM
  • Cryoprotein
  • Quantitative cryoglobulins
Cryoglobulin, Qualitative, with Reflex to Quantitative IgA, IgG, and IgM