Ordering Recommendation

Aids in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Fasting specimen required: Overnight or minimum of 8 hours fasting.


Plain red tube.

Specimen Preparation

1) Draw approximately 7 mL of blood into a prewarmed (37°C) plain red tube. Alternatively: draw into a prewarmed (37°C) syringe and immediately transfer blood to a prewarmed (37°C) plain red tube. 2) Maintain collected blood at 37°C until clotting is complete (up to 1 hour). 3) Separate serum from cells ASAP. Transfer 3 mL serum to an ARUP standard transport tube. (Min: 1 mL) See Remarks.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated.

Unacceptable Conditions

Plasma. Serum separator tubes (SST or other clot-activating tubes). Grossly hemolyzed or lipemic specimens.


Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.


After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: Unacceptable


Qualitative Cold Precipitation/Quantitative Nephelometry




3-5 days

Reference Interval

Interpretive Data

The sample is examined daily for the presence or absence of cryoglobulin.  

Interpretive Data
Cryoglobulin Qualitative Screen Negative at 72 hours.

Compliance Category

Laboratory Developed Test (LDT)


Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease.

If after three days cryoprecipitate is observed, then quantitative immunoglobulins (IgA, IgG, and IgM) will be added. Additional charges apply.

Hotline History


CPT Codes

82595; if reflexed, add 82784 x3


Component Test Code* Component Chart Name LOINC
0050188 Cryoglobulin Qualitative Screen 12203-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Cryoglobulins/cryoglobulins
  • Cryoglobulins reflex test to IgA, IgG, and IgM
  • Cryoprotein
  • Quantitative cryoglobulins
Cryoglobulin, Qualitative, with Reflex to Quantitative IgA, IgG, and IgM