Ordering Recommendation

Evaluate cutaneous photosensitivity to exclude or include porphyria cutanea tarda (PCT).

Mnemonic
PORURINE
Methodology

Quantitative High Performance Liquid Chromatography

Performed

Mon-Fri

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

24-hour or random urine. Refrigerate 24-hour specimens during collection.

Specimen Preparation

Protect from light. Transfer 4 mL aliquot of urine to an ARUP Amber Transport Tube. (Min: 2 mL) Record total volume and collection time interval on transport tube and test request form.

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Body fluids other than urine.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month

Reference Interval
Test Number
Components
Reference Interval
Uroporphyrin 0-4 µmol/mol crt
Heptacarboxylate Porphyrin 0-2 µmol/mol crt
Coproporphyrin I 0-6 µmol/mol crt
Coproporphyrin III 0-14 µmol/mol crt
0020473 Creatinine, Urine - per 24h
Age
Male
Female
3-8 years 140-700 mg/d 140-700 mg/d
9-12 years 300-1300 mg/d 300-1300 mg/d
13-17 years 500-2300 mg/d 400-1600 mg/d
18-50 years 1000-2500 mg/d 700-1600 mg/d
51-80 years 800-2100 mg/d 500-1400 mg/d
81 years and older 600-2000 mg/d 400-1300 mg/d

Interpretive Data

Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine).

Compliance Category

Laboratory Developed Test (LDT)

Note

Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias such as acute intermittent porphyria (AIP) requires urine porphobilinogen (PBG) testing. Refer to Porphobilinogen (PBG), Urine (ARUP test code 0080260). 

Hotline History
N/A
CPT Codes

84120

Components
Component Test Code* Component Chart Name LOINC
0020207 Creatinine, Urine - per volume 2161-8
0020208 Creatinine, Urine - per 24h 2162-6
0080365 Uroporphyrin - ratio to CRT 32043-2
0080366 Heptacarboxylate - ratio to CRT 38175-6
0080459 Porphyrin Urine Interpretation 49292-6
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
2002059 Coproporphyrin I - ratio to CRT 45313-4
2002061 Coproporphyrin III - ratio to CRT 45315-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Coproporphyrin
  • Heptacarboxyl Porphyrin
  • Hexacarboxyl Porphyrin
  • Pentacarboxyl Porphyrin
  • Porphyria Cutanea Tarda (PCT)
  • Porphyrins, Fractionated, Quantitative, 24-Hour
  • Uroporphyrin
Porphyrins, Fractionation and Quantitation, Urine