Ordering Recommendation

Evaluate cutaneous photosensitivity to exclude or include porphyria cutanea tarda (PCT).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

24-hour or random urine. Refrigerate 24-hour specimens during collection.

Specimen Preparation

Protect from light. Transfer 4 mL aliquot of urine to an ARUP Amber Transport Tube. (Min: 2 mL) Record total volume and collection time interval on transport tube and test request form.

Storage/Transport Temperature


Unacceptable Conditions

Body fluids other than urine.


Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month


Quantitative High Performance Liquid Chromatography (HPLC)




1-5 days

Reference Interval

Test Number
Reference Interval
  Creatinine, Urine - per 24h
Male (mg/d)
Female (mg/d)
3-8 years 140-700 140-700
9-12 years 300-1300 300-1300
13-17 years 500-2300 400-1600
18-50 years 1000-2500 700-1600
51-80 years 800-2100 500-1400
81 years and older 600-2000 400-1300

  Uroporphyrin - ratio to CRT 0-4 µmol/mol CRT
  Heptacarboxylate - ratio to CRT 0-2 µmol/mol CRT
  Coproporphyrin I - ratio to CRT 0-6 µmol/mol CRT
  Coproporphyrin III - ratio to CRT 0-14 µmol/mol CRT

Interpretive Data

Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine).

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias such as acute intermittent porphyria (AIP) requires urine porphobilinogen (PBG) testing. Refer to Porphobilinogen (PBG), Urine (ARUP test code 0080260). 

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0020207 Creatinine, Urine - per volume 2161-8
0020208 Creatinine, Urine - per 24h 2162-6
0080365 Uroporphyrin - ratio to CRT 32043-2
0080366 Heptacarboxylate - ratio to CRT 38175-6
0080459 Porphyrin Urine Interpretation 49292-6
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
2002059 Coproporphyrin I - ratio to CRT 45313-4
2002061 Coproporphyrin III - ratio to CRT 45315-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Coproporphyrin
  • Heptacarboxyl Porphyrin
  • Hexacarboxyl Porphyrin
  • Pentacarboxyl Porphyrin
  • Porphyria Cutanea Tarda (PCT)
  • Porphyrins, Fractionated, Quantitative, 24-Hour
  • Uroporphyrin
Porphyrins, Fractionation and Quantitation, Urine