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Congenital Adrenal Hyperplasia Treatment Panel

CAH RX PANEL
Example Reports
High
Normal

Ordering Recommendation

Use to monitor treatment of individuals with classic or nonclassic congenital adrenal hyperplasia.

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Collect between 6-10 a.m.

Collect

Serum separator tube or green (sodium or lithium heparin). Also acceptable: Pink (K2EDTA).

Specimen Preparation

Transfer 1.2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.7 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 6 months

Reference Interval

Test Number
 Components
 Reference Interval
  Testosterone by Mass Spec
Age
 Male (ng/dL)
 Female (ng/dL)
Premature (26-28 weeks) 59-125 5-16
Premature (31-35 weeks) 37-198 5-22
Newborn 75-400 20-64
1-5 months 14-363 Less than 20
6-24 months Less than 37 Less than 9
2-3 years Less than 15 Less than 20
4-5 years Less than 19 Less than 30
6-7 years Less than 13 Less than 7
8-9 years 2-8 1-11
10-11 years 2-165 3-32
12-13 years 3-619 6-50
14-15 years 31-733 6-52
16-17 years 158-826 9-58
18-39 years 300-1080 9-55
40-59 years 300-890 9-55
60 years and older 300-720 5-32
Premenopausal (18 years and older) Not Applicable 9-55
Postmenopausal Not Applicable 5-32
Tanner Stage I 2-15 2-17
Tanner Stage II 3-303 5-40
Tanner Stage III 10-851 10-63
Tanner Stage IV-V 162-847 11-62

  17-Hydroxyprogesterone, HPLC-MS/MS
Age
 Male (ng/dL)
 Female (ng/dL)
Premature (26-28 weeks) 124-841 124-841
Premature (29-35 weeks) 26-568 26-568
Full term Day 3 7-77 7-77
4 days-30 days Less than 200 7-106
1 month-2 months Less than 200 13-106
3 months-5 months 3-90 13-106
6 months-1 year Less than or equal to 148 Less than or equal to 148
2-3 years Less than or equal to 228 Less than or equal to 256
4-6 years Less than or equal to 208 Less than or equal to 299
7-9 years Less than or equal to 63 Less than or equal to 71
10-12 years Less than or equal to 79 Less than or equal to 129
13-15 years 9-140 9-208
16-17 years 24-192 Less than or equal to 178
18 years and older Less than 139 Less than 207
Follicular Not Applicable 15-70
Luteal Not Applicable 35-290
Tanner Stage I Less than or equal to 62 Less than or equal to 74
Tanner Stage II Less than or equal to 104 Less than or equal to 164
Tanner Stage III Less than or equal to 151 13-209
Tanner Stage IV-V 20-173 7-170

  Androstenedione by TMS
Age
 Male (ng/mL)
 Female (ng/mL)
Premature Infants (26-28 weeks Day 4) 0.92-2.82 0.92-2.82
Premature Infants (31-35 weeks Day 4) 0.80-4.46 0.80-4.46
Full Term Infants (1-7 days) 0.20-2.90 0.20-2.90
8-30 days 0.18-0.80 0.18-0.80
1-5 months 0.06-0.68 0.06-0.68
6-24 months 0.03-0.15 Less than 0.15
2-3 years Less than 0.11 Less than 0.16
4-5 years 0.02-0.17 0.02-0.21
6-7 years 0.01-0.29 0.02-0.28
8-9 years 0.03-0.30 0.04-0.42
10-11 years 0.07-0.39 0.09-1.23
12-13 years 0.10-0.64 0.24-1.73
14-15 years 0.18-0.94 0.39-2.00
16-17 years 0.30-1.13 0.35-2.12
18-39 years 0.33-1.34 0.26-2.14
40 years and older 0.23-0.89 0.13-0.82
Premenopausal Not Applicable 0.26-2.14
Postmenopausal Not Applicable 0.13-0.82
Tanner Stage I 0.04-0.32 0.05-0.51
Tanner Stage II 0.08-0.48 0.15-1.37
Tanner Stage III 0.14-0.87 0.37-2.24
Tanner Stage IV-V 0.27-1.07 0.35-2.05

Interpretive Data

Free or bioavailable testosterone measurements may provide supportive information.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

82157; 83498; 84403

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Components

Component Test Code* Component Chart Name LOINC
0081058 Testosterone by Mass Spec 2986-8
0092332 17-Hydroxyprogesterone, HPLC-MS/MS 1668-3
2001639 Androstenedione by TMS 1854-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 17-Hydroxyprogesterone (Congenital Adrenal Hyperplasia Treatment Panel)
  • Androstenedione (Congenital Adrenal Hyperplasia Treatment Panel)
  • Testosterone (Congenital Adrenal Hyperplasia Treatment Panel)
Congenital Adrenal Hyperplasia Treatment Panel