Celiac Disease Dual Antigen Screen with Reflex
Ordering Recommendation
Acceptable reflexive screening test for celiac disease. Positive screen results reflex to IgA and IgG antibody testing for tissue transglutaminase antibody (tTG) and deaminated gliadin peptide antibody (DGP). Preferred screening test is Celiac Disease Reflexive Cascade (2008114) or Tissue Transglutaminase (tTG) Antibody, IgA (0097709) testing.
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Mon, Wed, Fri
Reported
1-6 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)
Refrigerated.
Plasma. Contaminated, hemolyzed, or grossly lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Celiac Disease Dual Antigen Screen | 0 to 19 Units |
Interpretive Data
Refer to individual components.
Component | Interpretation | |
---|---|---|
Celiac Disease Dual Antigen Screen | 19 Units or less 20 Units or greater |
Negative - No significant level of detectable IgA or IgG antibodies against human tissue transglutaminase or gliadin peptide. Positive - Presence of IgA and/or IgG antibodies against human tissue transglutaminase and/or gliadin peptide; suggests possibility of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis. |
FDA
Note
The Celiac Disease Dual Antigen Screen is a combined antibody assay for tissue transglutaminase and deamidated gliadin-derived peptide antibodies, IgA and IgG.
If Celiac Disease Dual Antigen Screen is 20 Units or greater, then tTG IgA and Gliadin Peptide IgA will be added. If tTG IgA and Gliadin Peptide IgA are negative, tTG IgG and Gliadin Peptide IgG will be added. Additional charges apply.
Hotline History
CPT Codes
83516; if reflexed, add 86258 x2; 86364 x2
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0051691 | Celiac Disease Dual Antigen Screen | 63420-4 |
Aliases
- Anti-tissue Transglutaminase Antibody
- CD Dual Ag screen
- Celiac Sprue
- Deaminated Gliadin Peptide Antibodies
- DGP
- DGP IgA IgG
- Dual Ag reflex screen
- Dual antigen screen, Dual Ag screen
- Gluten Sensitivity Screen
- Gluten-Sensitive Enteropathy Tests
- tTG IgG, IgA