Celiac Disease Dual Antigen Screen with Reflex

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Example Reports
Negative
Positive

Ordering Recommendation

Acceptable reflexive screening test for celiac disease. Positive screen results reflex to IgA and IgG antibody testing for tissue transglutaminase antibody (tTG) and deaminated gliadin peptide antibody (DGP). Preferred screening test is Celiac Disease Reflexive Cascade (2008114) or Tissue Transglutaminase (tTG) Antibody, IgA (0097709) testing.

Mnemonic

CELIAC SCRN

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon, Wed, Fri

Reported

1-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Contaminated, hemolyzed, or grossly lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
Test Number
 Components
 Reference Interval
0051689 Celiac Disease Dual Antigen Screen
19 Units or less Negative - No significant level of detectable IgA or IgG antibodies against human tissue transglutaminase or gliadin peptide.
20 Units or greater Positive - Presence of IgA and/or IgG antibodies against human tissue transglutaminase and/or gliadin peptide; suggests possibility of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis.

0097709 Tissue Transglutaminase (tTG) Antibody, IgA
3 U/mL or less Negative
4-10 U/mL Weak Positive
11 U/mL or greater Positive

0056009 Tissue Transglutaminase Antibody, IgG
5 U/mL or less Negative
6-9 U/mL Weak Positive
10 U/mL or greater Positive

0051357 Deamidated Gliadin Peptide (DGP) Antibody, IgA
19 Units or less Negative
20-30 Units Weak Positive
31 Units or greater Positive

0051359 Deamidated Gliadin Peptide (DGP) Antibody, IgG
19 Units or less Negative
20-30 Units Weak Positive
31 Units or greater Positive

Interpretive Data

Refer to individual components.

Compliance Category

FDA

Note

The Celiac Disease Dual Antigen Screen is a combined antibody assay for tissue transglutaminase and deamidated gliadin-derived peptide antibodies, IgA and IgG.

If Celiac Disease Dual Antigen Screen is 20 Units or greater, then tTG IgA and Gliadin Peptide IgA will be added. If tTG IgA and Gliadin Peptide IgA are negative, tTG IgG and Gliadin Peptide IgG will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

83516; if reflexed, add 83516 x2; if further reflexed, add 83516 x2

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Components

Component Test Code* Component Chart Name LOINC
0051691 Celiac Disease Dual Antigen Screen 63420-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-tissue Transglutaminase Antibody
  • CD Dual Ag screen
  • Celiac Sprue
  • Deaminated Gliadin Peptide Antibodies
  • DGP
  • DGP IgA IgG
  • Dual Ag reflex screen
  • Dual antigen screen, Dual Ag screen
  • Gluten Sensitivity Screen
  • Gluten-Sensitive Enteropathy Tests
  • tTG IgG, IgA
Celiac Disease Dual Antigen Screen with Reflex