Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
POSACON AF
Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Tue, Thu, Sat

Reported

1-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. Blood levels may be affected by other concurrent medications, patient conditions, fat intake at dosing, and other factors.

Collect

Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube and freeze. (Min: 0.6 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Serum separator tubes. Hemolyzed or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months

Reference Interval

Effective August 15, 2011

Therapeutic Range (trough): Greater than 0.7 µg/mL

Interpretive Data

Adverse effects may include fever, nausea, vomiting, diarrhea, cardiac arrhythmias and liver toxicity.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80187

Components
Component Test Code* Component Chart Name LOINC
2001740 Posaconazole, Quantitative by LC-MS/MS 53731-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Noxafil
  • noxafil blood level
  • posaconazole blood level
  • Posanconazole
Posaconazole, Quantitative by LC-MS/MS