Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic

POSACON AF

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Tue, Thu, Sat

Reported

1-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. Blood levels may be affected by other concurrent medications, patient conditions, fat intake at dosing, and other factors.

Collect

Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube and freeze. (Min: 0.6 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Whole blood. Gel separator tubes, Light Blue (citrate), or Yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months

Reference Interval

Effective August 15, 2011

Therapeutic Range (trough): Greater than 0.7 µg/mL

Interpretive Data

Posaconazole is a triazole antifungal drug indicated to treat invasive aspergillus and candidiasis infections. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. The pharmacokinetics of posaconazole are influenced by drug-drug interactions when coadministered with drugs metabolized by UDP-glucuronosyltransferase. Posaconazole is also an inhibitor of cytochrome P450 3A4 enzyme. Adverse effects may include fever, nausea, vomiting, diarrhea, cardiovascular disorders, and liver toxicity.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80187

Components

Component Test Code* Component Chart Name LOINC
2001740 Posaconazole, Quantitative by LC-MS/MS 53731-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Noxafil
  • noxafil blood level
  • posaconazole blood level
  • Posanconazole
Posaconazole, Quantitative by LC-MS/MS