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Posaconazole, Quantitative by LC-MS/MS
Ordering Recommendation
Optimize drug therapy and monitor patient adherence.
New York DOH Approval Status
Specimen Required
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. Blood levels may be affected by other concurrent medications, patient conditions, fat intake at dosing, and other factors.
Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube and freeze. (Min: 0.6 mL)
Frozen.
Whole blood. Gel separator tubes, Light Blue (citrate), or Yellow (SPS or ACD solution).
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Thu, Sat
Reported
1-6 days
Reference Interval
Effective August 15, 2011
Therapeutic Range (trough): Greater than 0.7 µg/mL
Interpretive Data
Posaconazole is a triazole antifungal drug indicated to treat invasive aspergillus and candidiasis infections. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. The pharmacokinetics of posaconazole are influenced by drug-drug interactions when coadministered with drugs metabolized by UDP-glucuronosyltransferase. Posaconazole is also an inhibitor of cytochrome P450 3A4 enzyme. Adverse effects may include fever, nausea, vomiting, diarrhea, cardiovascular disorders, and liver toxicity.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
80187
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2001740 | Posaconazole, Quantitative by LC-MS/MS | 53731-6 |
Aliases
- Noxafil
- noxafil blood level
- posaconazole blood level
- Posanconazole
