Optimize drug therapy and monitor patient adherence.
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Specimens collected just before or within 15 minutes of the next dose represent the TROUGH levels. Specimens obtained within 15-30 minutes after the end of I.V. infusion or 45-60 minutes after an IM injection or 90 minutes after oral intake represent the PEAK level. Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL)
Separator tubes. Hemolyzed or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months
Effective February 19, 2013
|Therapeutic Range (trough)||1.0-6.0 µg/mL|
|Toxic Level||Greater than 6.0 µg/mL|
Toxic concentrations may cause nausea, vomiting, peripheral edema and elevated serum liver enzymes.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|2001738||Voriconazole, Quantitation by LC-MS/MS||38370-3|
- Vfend blood concentration
- voriconazole blood concentration