Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
VORICON AF
Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Tue-Sat

Reported

1-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Specimens collected just before or within 15 minutes of the next dose represent the TROUGH levels. Specimens obtained within 15-30 minutes after the end of I.V. infusion or 45-60 minutes after an IM injection or 90 minutes after oral intake represent the PEAK level. Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect

Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Separator tubes. Hemolyzed or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months

Reference Interval

Effective February 19, 2013

Therapeutic Range (trough) 1.0-6.0  µg/mL
Toxic Level Greater than 6.0 µg/mL

Interpretive Data

Toxic concentrations may cause nausea, vomiting, peripheral edema and elevated serum liver enzymes.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80285

Components
Component Test Code* Component Chart Name LOINC
2001738 Voriconazole, Quantitation by LC-MS/MS 38370-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Vfend
  • Vfend blood concentration
  • voriconazole blood concentration
Voriconazole, Quantitation by LC-MS/MS