Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Specimens collected just before or within 15 minutes of the next dose represent the TROUGH levels. Specimens obtained within 15-30 minutes after the end of I.V. infusion or 45-60 minutes after an IM injection or 90 minutes after oral intake represent the PEAK level. Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.


Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature


Unacceptable Conditions

Whole blood. Gel separator tubes, Light Blue (citrate), or Yellow (SPS or ACD solution).


After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months


Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry




1-6 days

Reference Interval

Effective February 19, 2013

Therapeutic Range (trough) 1.0-6.0  µg/mL
Toxic Level Greater than 6.0 µg/mL

Interpretive Data

Voriconazole is an azole antifungal drug indicated to treat invasive aspergillosis, candidiasis, scedosporiosis, and fusariosis infections. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. The pharmacokinetics of voriconazole are influenced by drug-drug interactions when coadministered with drugs metabolized by cytochrome P450 2C9, 2C19 and 3A4 enzymes. Adverse effects may include nausea, vomiting, tachycardia, and elevated serum liver enzymes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
2001738 Voriconazole, Quantitation by LC-MS/MS 38370-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Vfend
  • Vfend blood concentration
  • voriconazole blood concentration
Voriconazole, Quantitation by LC-MS/MS