Optimize drug therapy and monitor patient adherence.
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Specimens collected just before or within 15 minutes of the next dose represent the TROUGH levels. Specimens obtained within 15-30 minutes after the end of I.V. infusion or 45-60 minutes after an IM injection or 90 minutes after oral intake represent the PEAK level. Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL)
Separator tubes. Hemolyzed or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months
Effective February 19, 2013
|Therapeutic Range (trough)||1.0-6.0 µg/mL|
|Toxic Level||Greater than 6.0 µg/mL|
Toxic concentrations may cause nausea, vomiting, peripheral edema and elevated serum liver enzymes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|2001738||Voriconazole, Quantitation by LC-MS/MS||38370-3|
- Vfend blood concentration
- voriconazole blood concentration