Neisseria meningitidis Tetravalent Antibodies (Serogroups A, C, W-135 and Y), IgG
Use to assess immunocompetence following Neisseria meningitidis vaccination. To assess suspected immunodeficiency, use pre- and postvaccination serology. Do not use for diagnosis of infection or serotyping.
Quantitative Multiplex Bead Assay
Serum separator tube.
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
N. meningitidis A, C, W-135 and Y, IgG:
0.9 µg/mL or less: Antibody concentration not protective.
1.0-2.0 µg/mL: Equivocal.
2.1 µg/mL or greater: Antibody to Neisseria meningitidis detected. Suggestive of protection.
Responder status is determined according to the ratio of the one month post-vaccination concentration to pre-vaccination concentration of IgG antibodies to N. meningitidis (Types A, C, Y, and W-135) as follows:
1. If the one month post-vaccination concentration is less than 3.0 µg/mL, the patient is considered to be a non-responder.
2. If the one month post-vaccination concentration is greater than or equal to 3.0 µg/mL, a patient with a ratio of greater than or equal to 4 is a good responder, a ratio of 2-4 is a weak responder, and a ratio of less than 2 is considered a non-responder
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|2001604||N.meningitidis Type A IgG||28546-0|
|2001605||N.meningitidis Type C IgG||28547-8|
|2001606||N.meningitidis Type Y IgG||60466-0|
|2001607||N.meningitidis Type W-135 IgG||60465-2|
- Meningococcal IgG Vaccine Response
- N. Meningitidis IgG Vaccine Response
- Neisseria meningitidis
- Vaccine Response