Ordering Recommendation

Aid in the diagnosis of infection with arboviruses in CSF.

Mnemonic
ARBOCSF GM
Methodology

Semi-Quantitative Indirect Fluorescent Antibody/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue, Fri

Reported

1-5 days

New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 4 mL CSF to an ARUP Standard Transport Tube. (Min: 2.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, or hemolyzed specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Effective February 19, 2013

Components Reference Interval
St. Louis Encephalitis Antibody, IgG by IFA, CSF Less than 1:1
California Encephalitis Antibody, IgG by IFA, CSF Less than 1:1
Eastern Equine Encephalitis Antibody, IgG by IFA, CSF Less than 1:1
Western Equine Encephalitis Antibody, IgG by IFA, CSF Less than 1:1
West Nile Virus Antibody, IgG by ELISA, CSF 1.29 IV or less: Negative - No significant level of West Nile virus IgG antibody detected.
1.30-1.49 IV: Equivocal - Questionable presence of West Nile virus IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.50 IV or greater: Positive - Presence of IgG antibody to West Nile virus detected, suggestive of current or past infection.
St. Louis Encephalitis Antibody, IgM by IFA, CSF Less than 1:1
California Encephalitis Antibody, IgM by IFA, CSF Less than 1:1
Eastern Equine Encephalitis Antibody, IgM by IFA, CSF Less than 1:1
Western Equine Encephalitis, Antibody, IgM by IFA, CSF Less than 1:1
West Nile Virus Antibody, IgM by ELISA, CSF 0.89 IV or less: Negative - No significant level of West Nile virus IgM antibody detected.
0.90-1.10 IV: Equivocal - Questionable presence of West Nile virus IgM antibody detected.  Repeat testing in 10-14 days may be helpful.
1.11 IV or greater: Positive - Presence of IgM antibody to West Nile virus detected, suggestive of current or recent infection.

Interpretive Data

Refer to Report.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

86651 x2; 86652 x2; 86653 x2; 86654 x2; 86789; 86788

Components
Component Test Code* Component Chart Name LOINC
0050238 West Nile Virus Antibody IgG CSF 39572-3
0050239 West Nile Virus Antibody IgM CSF 39573-1
0098729 Eastern Equine Enceph Ab, IgM, CSF 10899-3
0098730 Western Equine Enceph Ab, IgM, CSF 9316-1
0098893 California Encephalitis IgG CSF 49138-1
0098895 St. Louis Encephalitis Ab, IgG, CSF 21509-5
0098896 Eastern Equine Enceph Ab, IgG, CSF 10897-7
0098897 Western Equine Enceph Ab, IgG, CSF 9315-3
0098898 California Encephalitis IgM CSF 9540-6
0098899 St. Louis Encephalitis Ab, IgM, CSF 21510-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Arbovirus
  • Arbovirus CSF antibodies
  • California Encephalitis Antibody, IgG CSF
  • California Encephalitis Antibody, IgM CSF
  • Eastern Equine Encephalitis Antibody, IgG CSF
  • Eastern Equine Encephalitis Antibody, IgM CSF
  • St. Louis Encephalitis Antibody, IgG CSF
  • St. Louis Encephalitis Antibody, IgM CSF
  • Viral Encephalitis
  • West Nile Virus Antibody, IgG CSF
  • West Nile Virus Antibody, IgM CSF
  • Western Equine Encephalitis Antibody CSF
  • Western Equine Encephalitis, Antibody, IgM CSF
Arbovirus Antibodies, IgG and IgM, CSF