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Hepatitis B Virus Genotype by Sequencing
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Ordering Recommendation
Determine antiviral drug resistance by DNA sequencing.
Mnemonic
Methodology
Polymerase Chain Reaction/Sequencing
Performed
Tue, Fri
Reported
Within 10 days
New York DOH Approval Status
Specimen Required
Lavender (EDTA), pink (K2EDTA), serum separator tube, or plasma preparation tube.
Separate serum or plasma from cells within 24 hours. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Frozen.
Heparinized specimens.
Ambient: 72 hours; Refrigerated: 1 week; Frozen: 6 weeks
Reference Interval
None
Interpretive Data
Both the HBV RT polymerase and the HBsAg encoding regions are sequenced. Resistance and surface antigen mutations are reported. In addition, the major HBV genotypes are identified. Mutations in viral sub-populations below 20 percent of total may not be detected.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
This test may be unsuccessful if the HBV viral load is less than log 3.0 or 1,000 IU/mL of plasma.
Hotline History
CPT Codes
87912
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2001568 | HBV Surface Antigen Mutations by Seq | 32366-7 |
| 2001569 | Hepatitis B Genotype by Seq | 32366-7 |
| 2001570 | HBV RT Polymerase Mutations by Seq | 49883-2 |
Aliases
- Adefovir
- Entecavir
- HBsAg mutations
- HBV drug resistance testing
- HBV Genotype
- HBV Genotyping
- HBV Resistance
- HBV Resistance Sequencing
- HBV Sequencing
- Hepatitis B Drug Resistance Panel
- Lamivudine
- Telbivudine
- Tenofovir
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