Ordering Recommendation

Aid in determination of the relative amount of anti-A or anti-B present in serum to evaluate an individual’s ability to mount an immune response. Most often performed on pediatric patients with recurrent infections. 






1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Lavender (K2EDTA), or Pink (K2EDTA).

Specimen Preparation

Do not freeze. Transport 14 mL whole blood. (Min: 6 mL)

Storage/Transport Temperature


Unacceptable Conditions

Separator or gel tubes.


Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

Normals are not applicable.

Interpretive Data

Compliance Category



 Isohemagglutinin titers contain both IgM and IgG. Both IgG and IgM titers will be performed for this test. If only IgM or IgG titer is desired, order Isohemagglutinin Titer, IgG (2000271) or Isohemagglutinin Titer, IgM (2000270). Specimens are screened for antibodies; if positive, an antibody panel will be performed. Titers will be performed as indicated for specific blood groups. Additional charges will apply to antibody identification and titer testing.

Hotline History


CPT Codes

86900; if blood type is A add: 86886, 86941; if blood type is B, add: 86886, 86941; if blood type is O, add: 86886 x2, 86941 x2. If blood type is AB, no additional titers will be performed.


Component Test Code* Component Chart Name LOINC
2000288 ABO Group ISO Interp 883-9
2000289 Anti A Titer IgM ISO 50762-4
2000290 Anti B Titer IgM ISO 50763-2
2000295 Anti A Titer IgG ISO 50761-6
2000296 Anti B Titer IgG ISO 50764-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Anti-A & B Titer
  • Isohemagglutinin Titer Anti-A
  • Isohemagglutinin Titer Anti-B
Isohemagglutinin Titer, IgG and IgM