Homocysteine, Total

0099869
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Example Reports
Abnormal
Normal

Ordering Recommendation

Acceptable screening test for disorders of methionine metabolism (congenital hyperhomocysteinemia). Not recommended for risk assessment of cardiovascular disease or venous thromboembolism.

Mnemonic

HOMOCY-QNT

Methodology

Quantitative Enzymatic

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Green (lithium heparin), serum separator tube, or EDTA (K2 and K3).

Specimen Preparation

Serum or plasma must be separated immediately after collection. If immediate centrifugation is not possible, collected blood specimens should be kept on ice and centrifuged within one hour. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Sodium citrate.

Remarks
Stability

Ambient: 4 days; Refrigerated: 1 month; Frozen: 10 months

Reference Interval

Effective January 4, 2021:
0-15 µmol/L, for both male and female

Interpretive Data

Elevated total homocysteine (tHcy) concentrations may be associated with vitamin B12 deficiency, folate deficiency, or inherited disorders of methionine metabolism. tHcy may also be used as a weak-graded risk factor for cardiovascular disease or stroke.

Compliance Category

FDA

Note

False elevations of plasma or serum homocysteine may occur if the plasma or serum is not promptly separated from the cells at the time of collection. Fasting specimen preferred.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
01/04/2021
X
X
N/A

CPT Codes

83090

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Components

Component Test Code* Component Chart Name LOINC
0099869 Homocysteine, Total 13965-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Plasma Total Homocysteine
Homocysteine, Total