Recommended first-line test for the evaluation of polymyositis or inflammatory myopathies.
Semi-Quantitative Multiplex Bead Assay
Serum separator tubes.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)
Plasma or other body fluids.
After separation from the cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|29 AU/mL or less||Negative|
|41 AU/mL or greater||Positive|
Presence of Jo-1 (antihistidyl transfer RNA [t-RNA] synthetase) antibody is associated with polymyositis and may also be seen in patients with dermatomyositis. Jo-1 antibody is associated with pulmonary involvement (interstitial lung disease), Raynaud phenomenon, arthritis, and mechanic's hands (implicated in antisynthetase syndrome).
No compliance statements are in use for this test.
Presence of Jo-1 antibody is found in patients with pure polymyositis, pure dermatomyositis, or myositis associated with another rheumatic disease or with interstitial lung disease.
|Component Test Code*||Component Chart Name||LOINC|
|0099592||Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG||33571-1|
- Anti-Jo-1 Antibody
- Antibodies to Jo 1 Antigen
- Autoantibodies to Jo 1 Antigen
- Histidyl-tRNA Synthetase Antibodies
- Jo 1 Antibodies
- Polymyositis Antibodies
- Synthetase Antibody