Recommended first-line test for the evaluation of polymyositis or inflammatory myopathies.
Semi-Quantitative Multiplex Bead Assay
New York DOH Approval Status
Serum separator tubes.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)
Plasma or other body fluids.
After separation from the cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|29 AU/mL or less||Negative|
|41 AU/mL or greater||Positive|
Presence of Jo-1 (antihistidyl transfer RNA [t-RNA] synthetase) antibody is associated with polymyositis and may also be seen in patients with dermatomyositis. Jo-1 antibody is associated with pulmonary involvement (interstitial lung disease), Raynaud phenomenon, arthritis, and mechanic's hands (implicated in antisynthetase syndrome).
Presence of Jo-1 antibody is found in patients with pure polymyositis, pure dermatomyositis, or myositis associated with another rheumatic disease or with interstitial lung disease.
|Component Test Code*||Component Chart Name||LOINC|
|0099592||Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG||33571-1|
- Anti-Jo-1 Antibody
- Antibodies to Jo 1 Antigen
- Autoantibodies to Jo 1 Antigen
- Histidyl-tRNA Synthetase Antibodies
- Jo 1 Antibodies
- Polymyositis Antibodies
- Synthetase Antibody