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Jo-1 Antibody, IgG
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Ordering Recommendation
Recommended first-line test for the evaluation of polymyositis or inflammatory myopathies.
Mnemonic
Methodology
Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
Specimen Required
Serum separator tubes.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)
Refrigerated.
Plasma or other body fluids.
After separation from the cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
| 29 AU/mL or less | Negative |
| 30-40 AU/mL | Equivocal |
| 41 AU/mL or greater | Positive |
Interpretive Data
Presence of Jo-1 (antihistidyl transfer RNA [t-RNA] synthetase) antibody is associated with polymyositis and may also be seen in patients with dermatomyositis. Jo-1 antibody is associated with pulmonary involvement (interstitial lung disease), Raynaud phenomenon, arthritis, and mechanic's hands (implicated in antisynthetase syndrome).
FDA
Note
Presence of Jo-1 antibody is found in patients with pure polymyositis, pure dermatomyositis, or myositis associated with another rheumatic disease or with interstitial lung disease.
Hotline History
CPT Codes
86235
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0099592 | Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG | 33571-1 |
Aliases
- Anti-Jo-1 Antibody
- Antibodies to Jo 1 Antigen
- Autoantibodies to Jo 1 Antigen
- Histidyl-tRNA Synthetase Antibodies
- Jo 1 Antibodies
- Polymyositis Antibodies
- Synthetase Antibody
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